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Gene Review

Rfc4  -  replication factor C (activator 1) 4

Mus musculus

Synonyms: A1, AI894123, AU040575, Activator 1 subunit 4, RFC37, ...
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High impact information on Rfc4

  • BACKGROUND: Both the A1- and A3-adenosine receptors (ARs) have been implicated in mediating the cardioprotective effects of adenosine [1].
  • In addition, the expression of the mouse A1 cDNA protects human HeLa cells from apoptosis when human A1 and A2 proteins are targeted by RNA interference [2].


  1. Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Funakoshi, H., Chan, T.O., Good, J.C., Libonati, J.R., Piuhola, J., Chen, X., MacDonnell, S.M., Lee, L.L., Herrmann, D.E., Zhang, J., Martini, J., Palmer, T.M., Sanbe, A., Robbins, J., Houser, S.R., Koch, W.J., Feldman, A.M. Circulation (2006) [Pubmed]
  2. Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines. Patry, C., Lemieux, B., Wellinger, R.J., Chabot, B. Mol. Cancer Ther. (2004) [Pubmed]
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