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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SDCCAG8  -  serologically defined colon cancer antigen 8

Homo sapiens

Synonyms: Antigen NY-CO-8, BBS16, CCCAP, CCCAP SLSN7, Centrosomal colon cancer autoantigen protein, ...
 
 
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Disease relevance of SDCCAG8

 

High impact information on SDCCAG8

  • Serum antibody to p53 and HOXB7 is positively associated with EOC, whereas NY-CO-8-specific antibody shows negative association [2].
  • The 2139 bp open reading frame of hCCCAP encodes an 82.5 kDa protein that is 71% identical to mCCCAP at the amino acid level and has the same predicted secondary structure [1].
  • Ectopically expressed full-length hCCCAP in human U2-osteosarcoma cells also displayed centrosomal localization during interphase and mitosis [1].

References

  1. Identification and characterization of the novel centrosome-associated protein CCCAP. Kenedy, A.A., Cohen, K.J., Loveys, D.A., Kato, G.J., Dang, C.V. Gene (2003) [Pubmed]
  2. Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. Erkanli, A., Taylor, D.D., Dean, D., Eksir, F., Egger, D., Geyer, J., Nelson, B.H., Stone, B., Fritsche, H.A., Roden, R.B. Cancer Res. (2006) [Pubmed]
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