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Gene Review:

SDCCAG3 - serologically defined colon cancer antigen 3

Homo sapiens

Synonyms: Antigen NY-CO-3, NY-CO-3, Serologically defined colon cancer antigen 3

Neznanov, N. et al.

Neznanov, Neznanova, Angres, Gudkov,

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High impact information on SDCCAG3

Therefore, SDCCAG3 can be viewed as a potential target for modulation of TNF response [1].
Based on these results, we presume that SDCCAG3 is important for protein trafficking and presentation of TNFR1 on the cell surface [1].
The expression of the coiledcoil domain as the dominant negative mutant form of SDCCAG3 made the NIH3T3 and HeLa cells resistant to TNF-specific apoptosis [1].

Biological context of SDCCAG3

We proposed that the SDCCAG3 function might be related to protein trafficking and secretion [1].

References

Serologically defined colon cancer antigen 3 is necessary for the presentation of TNF receptor 1 on cell surface. Neznanov, N., Neznanova, L., Angres, B., Gudkov, A.V. DNA Cell Biol. (2005) [Pubmed]

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