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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAN1A2  -  mannosidase, alpha, class 1A, member 2

Homo sapiens

Synonyms: Alpha-1,2-mannosidase IB, MAN1B, Mannosidase alpha class 1A member 2, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, Processing alpha-1,2-mannosidase IB
 
 

 

 

Summary

Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM]

 

 

Function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2.

 

 

High impact information on MAN1A2

References

  1. A novel strategy for preventing PERV transmission to human cells by remodeling the viral envelope glycoprotein. Miyagawa, S., Nakatsu, S., Hazama, K., Nakagawa, T., Kondo, A., Matsunami, K., Yamamoto, A., Yamada, J., Miyazawa, T., Shirakura, R. Xenotransplantation (2006) [Pubmed]
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