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Gene Review

GCNT2  -  glucosaminyl (N-acetyl) transferase 2, I...

Homo sapiens

Synonyms: CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, ...
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Disease relevance of GCNT2


High impact information on GCNT2


Chemical compound and disease context of GCNT2


Biological context of GCNT2


Anatomical context of GCNT2


Associations of GCNT2 with chemical compounds


Other interactions of GCNT2


Analytical, diagnostic and therapeutic context of GCNT2


  1. A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2 gene (GCNT2): association with autosomal recessive congenital cataracts. Pras, E., Raz, J., Yahalom, V., Frydman, M., Garzozi, H.J., Pras, E., Hejtmancik, J.F. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  2. A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene. Guilloux, Y., Lucas, S., Brichard, V.G., Van Pel, A., Viret, C., De Plaen, E., Brasseur, F., Lethé, B., Jotereau, F., Boon, T. J. Exp. Med. (1996) [Pubmed]
  3. Influenza virus entry and infection require host cell N-linked glycoprotein. Chu, V.C., Whittaker, G.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma. Endo, T., Nishimura, R., Kawano, T., Mochizuki, M., Kobata, A. Cancer Res. (1987) [Pubmed]
  5. Beta1,6-N-acetylglucosamine-bearing N-glycans in human gliomas: implications for a role in regulating invasivity. Yamamoto, H., Swoger, J., Greene, S., Saito, T., Hurh, J., Sweeley, C., Leestma, J., Mkrdichian, E., Cerullo, L., Nishikawa, A., Ihara, Y., Taniguchi, N., Moskal, J.R. Cancer Res. (2000) [Pubmed]
  6. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Bierhuizen, M.F., Mattei, M.G., Fukuda, M. Genes Dev. (1993) [Pubmed]
  7. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. Nishio, Y., Warren, C.E., Buczek-Thomas, J.A., Rulfs, J., Koya, D., Aiello, L.P., Feener, E.P., Miller, T.B., Dennis, J.W., King, G.L. J. Clin. Invest. (1995) [Pubmed]
  8. Partitioning of the Golgi apparatus during mitosis in living HeLa cells. Shima, D.T., Haldar, K., Pepperkok, R., Watson, R., Warren, G. J. Cell Biol. (1997) [Pubmed]
  9. Overlapping distribution of two glycosyltransferases in the Golgi apparatus of HeLa cells. Nilsson, T., Pypaert, M., Hoe, M.H., Slusarewicz, P., Berger, E.G., Warren, G. J. Cell Biol. (1993) [Pubmed]
  10. Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. Dosaka-Akita, H., Miyoshi, E., Suzuki, O., Itoh, T., Katoh, H., Taniguchi, N. Clin. Cancer Res. (2004) [Pubmed]
  11. Addition of beta1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin. Ihara, S., Miyoshi, E., Nakahara, S., Sakiyama, H., Ihara, H., Akinaga, A., Honke, K., Dickson, R.B., Lin, C.Y., Taniguchi, N. Glycobiology (2004) [Pubmed]
  12. Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases. Guo, P., Zhang, Y., Shen, Z.H., Zhang, X.Y., Chen, H.L. FEBS Lett. (2004) [Pubmed]
  13. Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates. Lazarus, B.D., Love, D.C., Hanover, J.A. Glycobiology (2006) [Pubmed]
  14. Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta. Tomiie, M., Isaka, S., Miyoshi, E., Taniguchi, N., Kimura, T., Ogita, K., Tsutsui, T., Shimoya, K., Nakagawa, T., Kondo, A., Koyama, M., Murata, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  15. Complementation of an Arabidopsis thaliana mutant that lacks complex asparagine-linked glycans with the human cDNA encoding N-acetylglucosaminyltransferase I. Gomez, L., Chrispeels, M.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. Shibukawa, Y., Takahashi, M., Laffont, I., Honke, K., Taniguchi, N. J. Biol. Chem. (2003) [Pubmed]
  17. Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase. Lazarus, B.D., Roos, M.D., Hanover, J.A. J. Biol. Chem. (2005) [Pubmed]
  18. N-Acetylglucosaminyltransferase III Antagonizes the Effect of N-Acetylglucosaminyltransferase V on {alpha}3beta1 Integrin-mediated Cell Migration. Zhao, Y., Nakagawa, T., Itoh, S., Inamori, K., Isaji, T., Kariya, Y., Kondo, A., Miyoshi, E., Miyazaki, K., Kawasaki, N., Taniguchi, N., Gu, J. J. Biol. Chem. (2006) [Pubmed]
  19. Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Reeves, P.J., Callewaert, N., Contreras, R., Khorana, H.G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  20. Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene. Buckhaults, P., Chen, L., Fregien, N., Pierce, M. J. Biol. Chem. (1997) [Pubmed]
  21. Biosynthesis of blood group I antigens. Identification of a UDP-GlcNAc:GlcNAc beta 1-3Gal(-R) beta 1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase in hog gastric mucosa. Piller, F., Cartron, J.P., Maranduba, A., Veyrières, A., Leroy, Y., Fournet, B. J. Biol. Chem. (1984) [Pubmed]
  22. Transcriptional regulation of the N-acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC-T1) is mediated by Ets-1. Kang, R., Saito, H., Ihara, Y., Miyoshi, E., Koyama, N., Sheng, Y., Taniguchi, N. J. Biol. Chem. (1996) [Pubmed]
  23. Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis. Sasaki, K., Kurata-Miura, K., Ujita, M., Angata, K., Nakagawa, S., Sekine, S., Nishi, T., Fukuda, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  24. Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome. Beltrán-Valero de Bernabé, D., Currier, S., Steinbrecher, A., Celli, J., van Beusekom, E., van der Zwaag, B., Kayserili, H., Merlini, L., Chitayat, D., Dobyns, W.B., Cormand, B., Lehesjoki, A.E., Cruces, J., Voit, T., Walsh, C.A., van Bokhoven, H., Brunner, H.G. Am. J. Hum. Genet. (2002) [Pubmed]
  25. Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II. Fukuda, M.N., Masri, K.A., Dell, A., Luzzatto, L., Moremen, K.W. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  26. Regulation of signal transduction pathways in development by glycosylation. Haltiwanger, R.S. Curr. Opin. Struct. Biol. (2002) [Pubmed]
  27. Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. Yeh, J.C., Ong, E., Fukuda, M. J. Biol. Chem. (1999) [Pubmed]
  28. The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein. Tan, J., D'Agostaro, A.F., Bendiak, B., Reck, F., Sarkar, M., Squire, J.A., Leong, P., Schachter, H. Eur. J. Biochem. (1995) [Pubmed]
  29. Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line. Beum, P.V., Bastola, D.R., Cheng, P.W. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  30. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Ishida, N., Kuba, T., Aoki, K., Miyatake, S., Kawakita, M., Sanai, Y. Genomics (2005) [Pubmed]
  31. Regulation on the expression and N-glycosylation of integrins by N-acetylglucosaminyltransferase V. Guo, P., Zhang, Y., Zhao, J.H., Wang, L.Y., Guo, H.B., Zhang, X.Y., Chen, H.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  32. An enzyme-linked immunosorbent assay for N-acetylglucosaminyltransferase-V. Crawley, S.C., Hindsgaul, O., Alton, G., Pierce, M., Palcic, M.M. Anal. Biochem. (1990) [Pubmed]
  33. Expression of a cytoplasmically epitope-tagged human Golgi glycosyltransferase in homologous cells results in mislocalization of multiple Golgi proteins. Yang, W., Storrie, B. Cell Biol. Int. (1997) [Pubmed]
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