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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lbw5  -  lupus NZB x NZW 5

Mus musculus

 
 
 
 
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Disease relevance of Lbw5

  • We examined rearrangements from pre-B cells, marginal zone B cells, and follicular B cells from mice congenic for the Lbw5 (Sle3/5) lupus susceptibility loci and from other strains of mice and found very few examples of CDR3 with D-D rearrangements [1].

References

  1. Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice. Watson, L.C., Moffatt-Blue, C.S., McDonald, R.Z., Kompfner, E., Ait-Azzouzene, D., Nemazee, D., Theofilopoulos, A.N., Kono, D.H., Feeney, A.J. J. Immunol. (2006) [Pubmed]
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