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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mice, Congenic

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Disease relevance of Mice, Congenic


High impact information on Mice, Congenic


Chemical compound and disease context of Mice, Congenic


Biological context of Mice, Congenic

  • Our findings show that, in B10.Q-V beta congenic mice, while the V beta a genotype does not prevent CIA, the highly truncated V beta c genotype renders B10.Q mice resistant to CIA [29].
  • We have found previously that mice congenic for a region of chromosome 1, containing the Duffy antigen/receptor for chemokines (DARC), have different susceptibility to P yoelii infection [30].
  • A higher incidence of Coombs antibody production in B6.Aia3 congenic mice (B6 mice bearing the NZB-Aia3 locus) than B6.Nba2 mice (B6 mice bearing the NZB-Nba2 locus) indicated a major role for Aia3 in AHA [31].
  • UCP1-deficient congenic mice have a very pronounced cold-sensitive phenotype; however, deficient mice on the F1 hybrid background were resistant to cold [32].
  • The greater NOD strain sensitivity was not a function of preexisting insulitis, because insulitis- and diabetes-free NOD male mice congenic for a diabetes-resistant major histocompatibility complex haplotype were equally susceptible to MD-STZ [33].

Anatomical context of Mice, Congenic

  • The results showed that such an anti-Id antiserum reacts specifically against anti-H-2k antibodies and against H-2k alloantigen-activated T cells from the following pairs of congenic mice: B10 (H-2b) and B10.D2 (H-2d); and A.BY (H-2b) and A.SW (H-2s), but not against C3H.SW (H-2b) and C3H.OH (H-2o); and BALB/b (H-2b) and BALB/c (H-2d) [34].
  • This interpretation accords well with evidence for MHC-restricted immune response to the same P. falciparum gamete surface antigens in studies with H-2 congenic mice (24) [35].
  • MMTV caused B cell activation in C3H/HeN mice but not in C3H/HeJ or BALB/c (C.C3H Tlr4(lps-d)) congenic mice, both of which have a mutant TLR4 gene [36].
  • The time course of the hematopoietic reconstitution of this primitive hematopoietic stem cell fraction was investigated by using Ly-5 congenic mice [37].
  • Peritoneal macrophages from NOR and Idd5 NOD congenic mice were more proficient at engulfment than their NOD counterparts [38].

Associations of Mice, Congenic with chemical compounds


Gene context of Mice, Congenic

  • The alloantiserum was raised in BALB/c (H-2d, Igh-1a) mice hyperimmunized with spleen cells of Igh allotype congenic mice, CB-20 (H-2d, Igh-1b) [44].
  • We confirmed the presence of Blmpf1 in MHC congenic mice and narrowed the region to 2.7 cM in a reduced MHC congenic strain [45].
  • These data suggest that the profound protection from diabetes seen in congenic mice carrying an Idd3 protective allele is unlikely to be due to differences in the level of expression of the Il2 gene [46].
  • We now confirm the existence of this locus using two lines of congenic mice bearing the B10.S Ifng locus on an SJL/J background, and we describe a deletion in the promoter of the Ifng gene of the SJL/J mouse [47].
  • The contribution of Nba2 to monocytosis was confirmed by the analysis of Yaa-bearing B6 mice congenic for the NZB-Nba2 locus [48].

Analytical, diagnostic and therapeutic context of Mice, Congenic


  1. Primary Sjögren's syndrome and deficiency of ICA69. Winer, S., Astsaturov, I., Cheung, R., Tsui, H., Song, A., Gaedigk, R., Winer, D., Sampson, A., McKerlie, C., Bookman, A., Dosch, H.M. Lancet (2002) [Pubmed]
  2. An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice. Bill, J., Appel, V.B., Palmer, E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. Indomethacin is a potent inhibitor of pristane and plastic disc induced plasmacytomagenesis in a hypersusceptible BALB/c congenic strain. Potter, M., Wax, J., Jones, G.M. Blood (1997) [Pubmed]
  4. Splenic marginal zone lymphomas of mice. Fredrickson, T.N., Lennert, K., Chattopadhyay, S.K., Morse, H.C., Hartley, J.W. Am. J. Pathol. (1999) [Pubmed]
  5. Crosses of NOD mice with the related NON strain. A polygenic model for IDDM. McAleer, M.A., Reifsnyder, P., Palmer, S.M., Prochazka, M., Love, J.M., Copeman, J.B., Powell, E.E., Rodrigues, N.R., Prins, J.B., Serreze, D.V. Diabetes (1995) [Pubmed]
  6. Recombinant congenic strains--a new tool for analyzing genetic traits determined by more than one gene. Démant, P., Hart, A.A. Immunogenetics. (1986) [Pubmed]
  7. Genetic composition of the recombinant congenic strains. Stassen, A.P., Groot, P.C., Eppig, J.T., Demant, P. Mamm. Genome. (1996) [Pubmed]
  8. Cancer susceptibility in the mouse: genetics, biology and implications for human cancer. Demant, P. Nat. Rev. Genet. (2003) [Pubmed]
  9. Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Lipoldová, M., Svobodová, M., Krulová, M., Havelková, H., Badalová, J., Nohýnková, E., Holán, V., Hart, A.A., Volf, P., Demant, P. Genes. Immun. (2000) [Pubmed]
  10. Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Lipoldová, M., Demant, P. Nat. Rev. Genet. (2006) [Pubmed]
  11. Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility. Lipoldová, M., Havelková, H., Badalová, J., Demant, P. Int. J. Cancer. (2005) [Pubmed]
  12. T-cell proliferative response is controlled by loci Tria4 and Tria5 on mouse chromosomes 7 and 9. Havelková, H., Kosarová, M., Krulová, M., Demant, P., Lipoldová, M. Mamm. Genome. (1999) [Pubmed]
  13. The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Kosarová, M., Havelková, H., Krulová, M., Demant, P., Lipoldová, M. Immunogenetics. (1999) [Pubmed]
  14. Genetic analysis of macrophage characteristics as a tool to identify tumor susceptibility genes: mapping of three macrophage-associated risk inflammatory factors, marif1, marif2, and marif3. Fijneman, R.J., Vos, M., Berkhof, J., Demant, P., Kraal, G. Cancer. Res. (2004) [Pubmed]
  15. Dual energy X ray absorptiometry of ex vivo HcB/Dem mouse long bones: left are denser than right. Franco, G.E., Litscher, S.J., O'Neil, T.K., Piette, M., Demant, P., Blank, R.D. Calcif. Tissue. Int. (2005) [Pubmed]
  16. Genetic characterization of the Dyscalc locus. Colinayo, V.V., Qiao, J.H., Demant, P., Krass, K., Lusis, A.J., Drake, T.A. Mamm. Genome. (2002) [Pubmed]
  17. Positional cloning of the combined hyperlipidemia gene Hyplip1. Bodnar, J.S., Chatterjee, A., Castellani, L.W., Ross, D.A., Ohmen, J., Cavalcoli, J., Wu, C., Dains, K.M., Catanese, J., Chu, M., Sheth, S.S., Charugundla, K., Demant, P., West, D.B., de Jong, P., Lusis, A.J. Nat. Genet. (2002) [Pubmed]
  18. Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene. Gouya, L., Muzeau, F., Robreau, A.M., Letteron, P., Couchi, E., Lyoumi, S., Deybach, J.C., Puy, H., Fleming, R., Demant, P., Beaumont, C., Grandchamp, B. Gastroenterology. (2007) [Pubmed]
  19. Mouse genetic model for antigen-induced airway manifestations of asthma. Piavaux, B., Jeurink, P.V., Groot, P.C., Hofman, G.A., Demant, P., Van Oosterhout, A.J. Genes. Immun. (2007) [Pubmed]
  20. Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Jin, F.Y., Nathan, C., Radzioch, D., Ding, A. Cell (1997) [Pubmed]
  21. Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide. Van Zant, G., Eldridge, P.W., Behringer, R.R., Dewey, M.J. Cell (1983) [Pubmed]
  22. Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice. Novak, R., Bosze, Z., Matkovics, B., Fachet, J. Science (1980) [Pubmed]
  23. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Vijayakrishnan, L., Slavik, J.M., Illés, Z., Greenwald, R.J., Rainbow, D., Greve, B., Peterson, L.B., Hafler, D.A., Freeman, G.J., Sharpe, A.H., Wicker, L.S., Kuchroo, V.K. Immunity (2004) [Pubmed]
  24. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. Foss, D.L., Donskoy, E., Goldschneider, I. J. Exp. Med. (2001) [Pubmed]
  25. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. Grob, P., Schijns, V.E., van den Broek, M.F., Cox, S.P., Ackermann, M., Suter, M. J. Virol. (1999) [Pubmed]
  26. Experimental myasthenia gravis in congenic mice. Sequence mapping and H-2 restriction of T helper epitopes on the alpha subunits of Torpedo californica and murine acetylcholine receptors. Bellone, M., Ostlie, N., Lei, S., Conti-Tronconi, B.M. Eur. J. Immunol. (1991) [Pubmed]
  27. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. Fletcher, R.T., Sanyal, S., Krishna, G., Aguirre, G., Chader, G.J. J. Neurochem. (1986) [Pubmed]
  28. Selective expression of antibody classes and contact sensitivity affected by genes in the major histocompatibility complex. Thomas, W.R., Watkins, M.C., Asherson, G.L. Scand. J. Immunol. (1979) [Pubmed]
  29. Collagen-induced arthritis in T cell receptor V beta congenic B10.Q mice. Nabozny, G.H., Bull, M.J., Hanson, J., Griffiths, M.M., Luthra, H.S., David, C.S. J. Exp. Med. (1994) [Pubmed]
  30. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion. Swardson-Olver, C.J., Dawson, T.C., Burnett, R.C., Peiper, S.C., Maeda, N., Avery, A.C. Blood (2002) [Pubmed]
  31. Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Kikuchi, S., Amano, H., Amano, E., Fossati-Jimack, L., Santiago-Raber, M.L., Moll, T., Ida, A., Kotzin, B.L., Izui, S. Blood (2005) [Pubmed]
  32. Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice. Hofmann, W.E., Liu, X., Bearden, C.M., Harper, M.E., Kozak, L.P. J. Biol. Chem. (2001) [Pubmed]
  33. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Gerling, I.C., Friedman, H., Greiner, D.L., Shultz, L.D., Leiter, E.H. Diabetes (1994) [Pubmed]
  34. Alloantigen-specific idiotype-bearing receptors on mouse T lymphocytes. I. Specificity characterization and genetic association with the heavy-chain IgG allotype. Rubin, B., Hertel-Wulff, B., Kimura, A. J. Exp. Med. (1979) [Pubmed]
  35. Restricted or absent immune responses in human populations to Plasmodium falciparum gamete antigens that are targets of malaria transmission-blocking antibodies. Carter, R., Graves, P.M., Quakyi, I.A., Good, M.F. J. Exp. Med. (1989) [Pubmed]
  36. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Rassa, J.C., Meyers, J.L., Zhang, Y., Kudaravalli, R., Ross, S.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  37. Sequential analysis of hematopoietic reconstitution achieved by transplantation of hematopoietic stem cells. Okada, S., Nagayoshi, K., Nakauchi, H., Nishikawa, S., Miura, Y., Suda, T. Blood (1993) [Pubmed]
  38. Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. O'Brien, B.A., Huang, Y., Geng, X., Dutz, J.P., Finegood, D.T. Diabetes (2002) [Pubmed]
  39. Role of the AKR gene locus AKv-1 in susceptibility to chemical induction of thymic lymphomas. Becker, F.F. Cancer Res. (1990) [Pubmed]
  40. Antigen-driven T cell clones can proliferate in vivo, eradicate disseminated leukemia, and provide specific immunologic memory. Klarnet, J.P., Matis, L.A., Kern, D.E., Mizuno, M.T., Peace, D.J., Thompson, J.A., Greenberg, P.D., Cheever, M.A. J. Immunol. (1987) [Pubmed]
  41. Priming for a cytotoxic response to minor histocompatibility antigens: antigen specificity and failure to demonstrate a carrier effect. Bevan, M.J. J. Immunol. (1977) [Pubmed]
  42. Inheritance of susceptibility to the myeloproliferative sarcoma virus: effect of the Fv-2 locus and evidence for a myeloproliferative sarcoma virus resistance locus. Ostertag, W., Odaka, T., Smadja-Joffe, F., Jasmin, C. J. Virol. (1981) [Pubmed]
  43. 2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype. Levy, G.N., Weber, W.W. Carcinogenesis (1992) [Pubmed]
  44. Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus. Tokuhisa, T., Taniguchi, M. J. Exp. Med. (1982) [Pubmed]
  45. Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice. Haston, C.K., Wang, M., Dejournett, R.E., Zhou, X., Ni, D., Gu, X., King, T.M., Weil, M.M., Newman, R.A., Amos, C.I., Travis, E.L. Hum. Mol. Genet. (2002) [Pubmed]
  46. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Lyons, P.A., Armitage, N., Argentina, F., Denny, P., Hill, N.J., Lord, C.J., Wilusz, M.B., Peterson, L.B., Wicker, L.S., Todd, J.A. Genome Res. (2000) [Pubmed]
  47. The Th1/Th2 balance does not account for the difference of susceptibility of mouse strains to Theiler's virus persistent infection. Monteyne, P., Bihl, F., Levillayer, F., Brahic, M., Bureau, J.F. J. Immunol. (1999) [Pubmed]
  48. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. Kikuchi, S., Santiago-Raber, M.L., Amano, H., Amano, E., Fossati-Jimack, L., Moll, T., Kotzin, B.L., Izui, S. J. Immunol. (2006) [Pubmed]
  49. Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice. Eckenrode, S.E., Ruan, Q., Yang, P., Zheng, W., McIndoe, R.A., She, J.X. Diabetes (2004) [Pubmed]
  50. Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain: Nramp1 influences T-helper subset responses and protection against leishmanial challenge. Soo, S.S., Villarreal-Ramos, B., Anjam Khan, C.M., Hormaeche, C.E., Blackwell, J.M. Infect. Immun. (1998) [Pubmed]
  51. High level expression of the plasma cell antigen PC.1 on the T-cell subset expanding in MRL/MpJ-lpr/lpr mice: detection with a xenogeneic monoclonal antibody and alloantisera. Dumont, F.J., Habbersett, R.C., Coker, L.Z., Nichols, E.A., Treffinger, J.A. Cell. Immunol. (1985) [Pubmed]
  52. A congenic line of the DDD mouse strain, DDD/1-Mtv-2/Mtv-2: establishment and mammary tumorigenesis. Matsuzawa, A., Sayama, K., Tsubura, A., Murakami, A. Jpn. J. Cancer Res. (1990) [Pubmed]
  53. Comparison of the lens crystallin proteins from normal, rd, and rds mutant mice utilizing specific monoclonal antibodies. Carper, D., Russell, P., Sanyal, S. Exp. Eye Res. (1985) [Pubmed]
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