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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HNRNPA0  -  heterogeneous nuclear ribonucleoprotein A0

Homo sapiens

Synonyms: HNRPA0, Heterogeneous nuclear ribonucleoprotein A0, hnRNP A0, hnRNPA0
 
 
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High impact information on HNRPA0

  • MAPKAP-K2 phosphorylated hnRNP A0 at Ser84 in vitro and this residue became phosphorylated in LPS-stimulated cells [1].
  • Our data suggest that LPS-induced binding of hnRNP A0 to AREs may contribute to the post-transcriptional regulation of specific mRNAs [1].
  • Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs [1].
  • This protein was affinity isolated using a biotinylated RNA probe [G4(AU3)4A] designed to select a 32-kDa protein implicated in mRNA stability in mammalian cells. hnRNP A0 is a basic protein with a predicted mass of 31.7 kDa and an isoelectric point of 10 [2].
 

Other interactions of HNRPA0

  • Here, we identify 18 macrophage proteins that bind to AREs and show that hnRNP A0 is a major substrate for MAPKAP-K2 in this fraction [1].

References

  1. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Rousseau, S., Morrice, N., Peggie, M., Campbell, D.G., Gaestel, M., Cohen, P. EMBO J. (2002) [Pubmed]
  2. Isolation and characterization of a novel, low abundance hnRNP protein: A0. Myer, V.E., Steitz, J.A. RNA (1995) [Pubmed]
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