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Gene Review:

Nidd3 - non-insulin-dependent diabetes mellitus 3

Mus musculus

Pan, H.J. et al., Leiter, E.H. et al.

Leiter, Reifsnyder, Flurkey, Partke, Junger, Herberg,

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Disease relevance of Nidd3

An NZO-derived diabetogenic region on Chr 11 (Nidd3), possibly comprising two separate loci, reduced ability to sustain elevated plasma insulin and significantly reduced weight gain over time [1].

High impact information on Nidd3

The gene encoding phosphatidylcholine transfer protein (PC-TP) is sited within the support interval for Nidd3, a recessive NZO-derived locus on Chromosome 11 identified by prior segregation analysis between NZO/HlLt and NON/Lt [2].

References

NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Leiter, E.H., Reifsnyder, P.C., Flurkey, K., Partke, H.J., Junger, E., Herberg, L. Diabetes (1998) [Pubmed]
A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Pan, H.J., Agate, D.S., King, B.L., Wu, M.K., Roderick, S.L., Leiter, E.H., Cohen, D.E. FEBS Lett. (2006) [Pubmed]

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