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Gene Review

Pctp  -  phosphatidylcholine transfer protein

Mus musculus

Synonyms: PC-TP, Phosphatidylcholine transfer protein, START domain-containing protein 2, StAR-related lipid transfer protein 2, StARD2, ...
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High impact information on Pctp

  • Phosphatidylcholine transfer protein (Pc-tp) is a highly specific carrier of phosphatidylcholine (PC) without known function [1].
  • Absence of Pc-tp in bone marrow-derived mast cells does not affect their lipid composition or PC synthesis and degradation [1].
  • In adult mice, Pc-tp levels are high only in epididymis, testis, kidney, and bone marrow-derived mast cells [1].
  • We discuss how PC might reach the canalicular membrane of the hepatocyte for secretion into the bile, if not by Pc-tp [1].
  • Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice [2].

Biological context of Pctp


Anatomical context of Pctp


Associations of Pctp with chemical compounds

  • In response to the lithogenic diet, a greater reduction in cholesterol 7alpha-hydroxylase activity in Pctp-/- mice could be attributed to increased size and hydrophobicity of the bile salt pool [8].
  • Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces [1].
  • PC-TP containing a PC species carrying an sn-1 palmitoyl chain was less stable than PC-TP containing a PC species carrying an sn-1 stearoyl chain given that these complexes were dissociated for 50% at a cv of roughly 30 and 45 V, respectively [9].
  • The various techniques which have been applied to establish the phospholipid localization include the following: phospholipase A2, phospholipase C, and sphingomyelinase C treatment, fluorescamine labeling of phosphatidylethanolamine, and a phosphatidylcholine transfer protein mediated exchange procedure [10].

Regulatory relationships of Pctp

  • In tissue culture systems, PC-TP promotes ATP-binding cassette protein A1-mediated efflux of cholesterol and phosphatidylcholine molecules as nascent pre-beta-high-density lipoprotein (HDL) particles [3].
  • In chow-fed mice, neither plasma cholesterol concentrations nor the concentrations and compositions of plasma phospholipids were influenced by PC-TP expression [3].

Other interactions of Pctp


Analytical, diagnostic and therapeutic context of Pctp

  • Sequence analysis revealed that the NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains [11].


  1. Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. van Helvoort, A., de Brouwer, A., Ottenhoff, R., Brouwers, J.F., Wijnholds, J., Beijnen, J.H., Rijneveld, A., van der Poll, T., van der Valk, M.A., Majoor, D., Voorhout, W., Wirtz, K.W., Elferink, R.P., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice. Wang, W.J., Baez, J.M., Maurer, R., Dansky, H.M., Cohen, D.E. J. Lipid Res. (2006) [Pubmed]
  3. Phosphatidylcholine transfer protein regulates size and hepatic uptake of high-density lipoproteins. Wu, M.K., Cohen, D.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  4. Phospholipid transfer proteins: from lipid monolayers to cells. Wirtz, K.W. Klin. Wochenschr. (1991) [Pubmed]
  5. Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein. Cohen, D.E., Green, R.M., Wu, M.K., Beier, D.R. Biochim. Biophys. Acta (1999) [Pubmed]
  6. Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein. Baez, J.M., Tabas, I., Cohen, D.E. Biochem. J. (2005) [Pubmed]
  7. Molecular cloning and characterization of phosphatidylcholine transfer protein-like protein gene expressed in murine haploid germ cells. Yamanaka, M., Koga, M., Tanaka, H., Nakamura, Y., Ohta, H., Yomogida, K., Tsuchida, J., Iguchi, N., Nojima, H., Nozaki, M., Matsumiya, K., Okuyama, A., Toshimori, K., Nishimune, Y. Biol. Reprod. (2000) [Pubmed]
  8. Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice. Wu, M.K., Cohen, D.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  9. Determination of the stability of the noncovalent phospholipid transfer protein-lipid complex by electrospray time-of-flight mass spectrometry. de Brouwer, A.P., Versluis, C., Westerman, J., Roelofsen, B., Heck, A.J., Wirtz, K.W. Biochemistry (2002) [Pubmed]
  10. Phospholipid localization in the plasma membrane of Friend erythroleukemic cells and mouse erythrocytes. Rawyler, A., van der Schaft, P.H., Roelofsen, B., Op den Kamp, J.A. Biochemistry (1985) [Pubmed]
  11. A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Pan, H.J., Agate, D.S., King, B.L., Wu, M.K., Roderick, S.L., Leiter, E.H., Cohen, D.E. FEBS Lett. (2006) [Pubmed]
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