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Gene Review

Hyal3  -  hyaluronoglucosaminidase 3

Mus musculus

Synonyms: Hyal-3, Hyaluronidase-3, Hyaluronoglucosaminidase-3, Hyl3
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High impact information on Hyal3

  • As a first step in the generation of mice with hyaluronidase deficiency, we have used experimental and bioinformatic approaches to examine the organization of the mouse chromosome 9 region containing, in order, Hyal2, Hyal1, and Hyal3 [1].
  • Interestingly, transcripts for the testicular-type hyaluronidase PH-20 (Spam1, Hyal3) were also detected in normal and autoimmune kidneys as well as in tubular cells and macrophages [2].


  1. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. Shuttleworth, T.L., Wilson, M.D., Wicklow, B.A., Wilkins, J.A., Triggs-Raine, B.L. J. Biol. Chem. (2002) [Pubmed]
  2. Expression profile of hyaluronidase mRNA transcripts in the kidney and in renal cells. Sun, L., Feusi, E., Sibalic, A., Beck-Schimmer, B., Wüthrich, R.P. Kidney Blood Press. Res. (1998) [Pubmed]
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