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Gene Review

HYAL3  -  hyaluronoglucosaminidase 3

Homo sapiens

Synonyms: HYAL-3, Hyal-3, Hyaluronidase-3, Hyaluronoglucosaminidase-3, LUCA-3, ...
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Disease relevance of HYAL3

  • Using bladder tissues and cells, prostate cancer cells, and kidney tissues and performing reverse transcription-PCR, cDNA cloning, DNA sequencing, and in vitro translation, we identified splice variants of HYAL1 and HYAL3 [1].
  • In a small set of breast tumor samples, no elevations in hyal-1, hyal-2 or LUCA3 mRNA were seen [2].


  1. Regulation of hyaluronidase activity by alternative mRNA splicing. Lokeshwar, V.B., Schroeder, G.L., Carey, R.I., Soloway, M.S., Iida, N. J. Biol. Chem. (2002) [Pubmed]
  2. Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer. Patel, S., Turner, P.R., Stubberfield, C., Barry, E., Rohlff, C.R., Stamps, A., McKenzie, E., Young, K., Tyson, K., Terrett, J., Box, G., Eccles, S., Page, M.J. Int. J. Cancer (2002) [Pubmed]
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