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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TMED10  -  transmembrane emp24-like trafficking...

Homo sapiens

Synonyms: 21 kDa transmembrane-trafficking protein, P24(DELTA), S31I125, S31III125, TMP21, ...
 
 
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Disease relevance of TMED10

 

High impact information on TMED10

  • A deletional analysis revealed that the C1 domain in chimaerins is required for the interaction with Tmp21-I, thereby implying a novel function for this domain in protein-protein associations in addition to its role in lipid and phorbol ester binding [2].
  • We further show the cloning and characterization of the human homologs, hum-Tmp21, which is expressed in two variants (Tmp21-I and Tmp21-II), and hum-p24A [3].
  • TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity [4].
 

Biological context of TMED10

References

  1. Hepatitis delta virus antigen forms dimers and multimeric complexes in vivo. Wang, J.G., Lemon, S.M. J. Virol. (1993) [Pubmed]
  2. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. Wang, H., Kazanietz, M.G. J. Biol. Chem. (2002) [Pubmed]
  3. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. Blum, R., Feick, P., Puype, M., Vandekerckhove, J., Klengel, R., Nastainczyk, W., Schulz, I. J. Biol. Chem. (1996) [Pubmed]
  4. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Chen, F., Hasegawa, H., Schmitt-Ulms, G., Kawarai, T., Bohm, C., Katayama, T., Gu, Y., Sanjo, N., Glista, M., Rogaeva, E., Wakutani, Y., Pardossi-Piquard, R., Ruan, X., Tandon, A., Checler, F., Marambaud, P., Hansen, K., Westaway, D., St George-Hyslop, P., Fraser, P. Nature (2006) [Pubmed]
  5. A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II. Hörer, J., Blum, R., Feick, P., Nastainczyk, W., Schulz, I. DNA Seq. (1999) [Pubmed]
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