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Gene Review

Ly7  -  lymphocyte antigen 7

Mus musculus

Synonyms: Ly-7
 
 
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High impact information on Ly7

  • Studies of the progeny of a B10.BR x (C3H/HeJ x B10.BR)F1 backcross confirmed the existence of two V beta 3+ T cell deleting genes: one unlinked and one linked to Ly-7, which we propose be called Mls-2 and Mls-3, respectively [1].
  • Murine lymphocyte alloantigens. II. The Ly-7 locus [2].
  • Direct testing by cytotoxicity and protein A rosetting showed that Ly-7 is expressed in very low amounts on thymocytes, but is readily detectable on more mature T and B lymphocytes (including antibody-forming cells), with the greatest expression on B cells [2].
  • Location of Ly-7 on mouse chromosome 12 [3].
  • Lymphocyte antigens: Ly-4, Ly-6, and Ly-7 [4].

References

  1. Evidence that Mls-2 antigens which delete V beta 3+ T cells are controlled by multiple genes. Pullen, A.M., Marrack, P., Kappler, J.W. J. Immunol. (1989) [Pubmed]
  2. Murine lymphocyte alloantigens. II. The Ly-7 locus. Potter, T.A., Morgan, G.M., McKenzie, I.F. J. Immunol. (1980) [Pubmed]
  3. Location of Ly-7 on mouse chromosome 12. Hogarth, P.M., McKenzie, I.F., Lanier, L., Bailey, D.W., Taylor, B.A. Immunogenetics (1984) [Pubmed]
  4. Lymphocyte antigens: Ly-4, Ly-6, and Ly-7. McKenzie, I.F., Gardiner, J., Cherry, M., Snell, G.D. Transplant. Proc. (1977) [Pubmed]
 
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