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Gene Review:

SCO4921 - acyl-CoA carboxylase complex A subunit

Streptomyces coelicolor A3(2)

Synonyms: SCK13.13c, accA2

Rodríguez, E. et al.

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Disease relevance of SCO4921

Two genes, accA1 and accA2, with nearly identical nucleotide sequences were cloned from Streptomyces coelicolor A3(2) [1].

High impact information on SCO4921

Heterologous expression of accA1, accA2 and pccB in Escherichia col and in vitro reconstitution of enzyme activity confirmed that PccB is the beta subunit of a propionyl-CoA carboxylase and that either AccA1 or AccA2 could act as the alpha component of this enzyme complex [1].

References

Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). Rodríguez, E., Gramajo, H. Microbiology (Reading, Engl.) (1999) [Pubmed]

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