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Gene Review: 

SCO6271  -  acyl-CoA carboxylase complex A subunit

Streptomyces coelicolor A3(2)

Synonyms: SC2C4.01c, SCAH10.36c, accA1
 
 
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Disease relevance of SCO6271

  • A derivative of BAP1 was engineered that harbors the AHBA biosynthetic operon, the bicistronic RifA construct and the pccB and accA1 genes from Streptomyces coelicolor, which enable methylmalonyl-CoA biosynthesis [1].
 

High impact information on SCO6271

  • Strains disrupted in accA1 did not show any change in acetyl- or propionyl-CoA carboxylase activity, whilst cell-free extracts of a pccB mutant strain contained a reduced level of propionyl-CoA carboxylase [2].
  • Heterologous expression of accA1, accA2 and pccB in Escherichia col and in vitro reconstitution of enzyme activity confirmed that PccB is the beta subunit of a propionyl-CoA carboxylase and that either AccA1 or AccA2 could act as the alpha component of this enzyme complex [2].
 

Biological context of SCO6271

References

  1. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Watanabe, K., Rude, M.A., Walsh, C.T., Khosla, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). Rodríguez, E., Gramajo, H. Microbiology (Reading, Engl.) (1999) [Pubmed]
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