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Gene Review:

SCO4926 - propionyl-CoA carboxylase complex B subunit

Streptomyces coelicolor A3(2)

Synonyms: SCK13.18c, pccB

Watanabe, K. et al., Rodríguez, E. et al.

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Disease relevance of SCO4926

A derivative of BAP1 was engineered that harbors the AHBA biosynthetic operon, the bicistronic RifA construct and the pccB and accA1 genes from Streptomyces coelicolor, which enable methylmalonyl-CoA biosynthesis [1].

High impact information on SCO4926

A gene, pccB, encoding the carboxyl transferase subunit of this enzyme complex was also characterized [2].
Strains disrupted in accA1 did not show any change in acetyl- or propionyl-CoA carboxylase activity, whilst cell-free extracts of a pccB mutant strain contained a reduced level of propionyl-CoA carboxylase [2].

References

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Watanabe, K., Rude, M.A., Walsh, C.T., Khosla, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). Rodríguez, E., Gramajo, H. Microbiology (Reading, Engl.) (1999) [Pubmed]

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