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Gene Review

SCO5216  -  RNA polymerase sigma factor RpoE

Streptomyces coelicolor A3(2)

Synonyms: SC7E4.13, sigR
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High impact information on SCO5216

  • Upon reestablishment of normal thiol levels, sigmaR activity is switched off, resulting in down-regulation of trxBA and sigR [1].
  • Deletion of the gene (sigR) encoding sigmaR caused sensitivity to the thiol-specific oxidant diamide and to the redox cycling compounds menadione and plumbagin [1].
  • In addition, the level of the major actinomycete thiol buffer, mycothiol, was fourfold lower in a sigR null mutant, although no candidate mycothiol biosynthetic genes were identified among the sigmaR targets [2].


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