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Gene Review:

SCO5216 - RNA polymerase sigma factor RpoE

Streptomyces coelicolor A3(2)

Synonyms: SC7E4.13, sigR

Paget, M.S. et al., Paget, M.S. et al.

Paget, Kang, Roe, Buttner, Paget, Molle, Cohen, Aharonowitz, Buttner,

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High impact information on SCO5216

Upon reestablishment of normal thiol levels, sigmaR activity is switched off, resulting in down-regulation of trxBA and sigR [1].
Deletion of the gene (sigR) encoding sigmaR caused sensitivity to the thiol-specific oxidant diamide and to the redox cycling compounds menadione and plumbagin [1].
In addition, the level of the major actinomycete thiol buffer, mycothiol, was fourfold lower in a sigR null mutant, although no candidate mycothiol biosynthetic genes were identified among the sigmaR targets [2].

References

sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2). Paget, M.S., Kang, J.G., Roe, J.H., Buttner, M.J. EMBO J. (1998) [Pubmed]
Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigmaR regulon. Paget, M.S., Molle, V., Cohen, G., Aharonowitz, Y., Buttner, M.J. Mol. Microbiol. (2001) [Pubmed]

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