Chemical Compound Review:
Vicasol 2-methylnaphthalene-1,4-dione
Synonyms:
Aquinone, Kaergona, Kappaxan, menadione, Vitamin K3, ...
- Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy. Mauzeroll, J., Bard, A.J., Owhadian, O., Monks, T.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene. Keightley, J.A., Anitori, R., Burton, M.D., Quan, F., Buist, N.R., Kennaway, N.G. Am. J. Hum. Genet. (2000)
- Excess release of ferriheme in G6PD-deficient erythrocytes: possible cause of hemolysis and resistance to malaria. Janney, S.K., Joist, J.J., Fitch, C.D. Blood (1986)
- Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases. Beall, H.D., Mulcahy, R.T., Siegel, D., Traver, R.D., Gibson, N.W., Ross, D. Cancer Res. (1994)
- Cellular defense mechanisms against toxic substances. Jones, T.W., Thor, H., Orrenius, S. Arch. Toxicol. Suppl. (1986)
- Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Hockenbery, D.M., Oltvai, Z.N., Yin, X.M., Milliman, C.L., Korsmeyer, S.J. Cell (1993)
- Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription. Liu, X.D., Thiele, D.J. Genes Dev. (1996)
- Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. Yeaman, M.R., Bayer, A.S., Koo, S.P., Foss, W., Sullam, P.M. J. Clin. Invest. (1998)
- Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. Ripple, M.O., Henry, W.F., Rago, R.P., Wilding, G. J. Natl. Cancer Inst. (1997)
- Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells. Barchowsky, A., Tabrizi, K., Kent, R.S., Whorton, A.R. J. Clin. Invest. (1989)
- Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Chuang, Y.Y., Chen, Y., Gadisetti, n.u.l.l., Chandramouli, V.R., Cook, J.A., Coffin, D., Tsai, M.H., DeGraff, W., Yan, H., Zhao, S., Russo, A., Liu, E.T., Mitchell, J.B. Cancer Res. (2002)
- Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool. Akman, S.A., Dietrich, M., Chlebowski, R., Limberg, P., Block, J.B. Cancer Res. (1985)
- Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species. Ateghang, B., Wartenberg, M., Gassmann, M., Sauer, H. J. Cell. Sci. (2006)
- Ethanol potentiates oxygen uptake and toxicity due to menadione bisulfite in perfused rat liver. Ganey, P.E., Takei, Y., Kauffman, F.C., Thurman, R.G. Mol. Pharmacol. (1990)
- Effects of menadione and hydrogen peroxide on glutathione status in growing Escherichia coli. Smirnova, G.V., Muzyka, N.G., Glukhovchenko, M.N., Oktyabrsky, O.N. Free Radic. Biol. Med. (2000)
- Prevention by menadione of the hepatotoxic effects in chickens fed rapeseed meal. Observations on coagulation factors and cytochrome P-450. Israels, E.D., Papas, A., Campbell, L.D., Israels, L.G. Gastroenterology (1979)
- Endogenous oxidative damage of deoxycytidine in DNA. Wagner, J.R., Hu, C.C., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1992)
- The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Desmots, F., Russell, H.R., Lee, Y., Boyd, K., McKinnon, P.J. Mol. Cell. Biol. (2005)
- Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Lash, L.H., Hagen, T.M., Jones, D.P. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Intracellular ferriprotoporphyrin IX is a lytic agent. Fitch, C.D., Chevli, R., Kanjananggulpan, P., Dutta, P., Chevli, K., Chou, A.C. Blood (1983)
- Alteration of Na+ homeostasis as a critical step in the development of irreversible hepatocyte injury after adenosine triphosphate depletion. Carini, R., Bellomo, G., Benedetti, A., Fulceri, R., Gamberucci, A., Parola, M., Dianzani, M.U., Albano, E. Hepatology (1995)
- Altered oxidative stress responses in nickel-resistant mammalian cells. Salnikow, K., Gao, M., Voitkun, V., Huang, X., Costa, M. Cancer Res. (1994)
- Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. Patel, K.D., Zimmerman, G.A., Prescott, S.M., McEver, R.P., McIntyre, T.M. J. Cell Biol. (1991)
- sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2). Paget, M.S., Kang, J.G., Roe, J.H., Buttner, M.J. EMBO J. (1998)
- Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Zhao, H., Joseph, J., Fales, H.M., Sokoloski, E.A., Levine, R.L., Vasquez-Vivar, J., Kalyanaraman, B. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Eggler, A.L., Liu, G., Pezzuto, J.M., van Breemen, R.B., Mesecar, A.D. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli. Eide, L., Bjørås, M., Pirovano, M., Alseth, I., Berdal, K.G., Seeberg, E. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Rodríguez-Manzaneque, M.T., Ros, J., Cabiscol, E., Sorribas, A., Herrero, E. Mol. Cell. Biol. (1999)
- Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Swanson, R.L., Morey, N.J., Doetsch, P.W., Jinks-Robertson, S. Mol. Cell. Biol. (1999)
- CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Schattenberg, J.M., Wang, Y., Rigoli, R.M., Koop, D.R., Czaja, M.J. Hepatology (2004)
- The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis. Ortiz, E.M., Dusetti, N.J., Vasseur, S., Malka, D., Bödeker, H., Dagorn, J.C., Iovanna, J.L. Gastroenterology (1998)
- 2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade. Klotz, L.O., Patak, P., Ale-Agha, N., Buchczyk, D.P., Abdelmohsen, K., Gerber, P.A., von Montfort, C., Sies, H. Cancer Res. (2002)
- Role of oxygen radicals in 12-O-tetradecanoylphorbol-13-acetate-induced squamous differentiation of cultured normal human bronchial epithelial cells. Gabrielson, E.W., Rosen, G.M., Grafstrom, R.C., Strauss, K.E., Miyashita, M., Harris, C.C. Cancer Res. (1988)
- Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. Cabiscol, E., Piulats, E., Echave, P., Herrero, E., Ros, J. J. Biol. Chem. (2000)
- Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells. Criddle, D.N., Gillies, S., Baumgartner-Wilson, H.K., Jaffar, M., Chinje, E.C., Passmore, S., Chvanov, M., Barrow, S., Gerasimenko, O.V., Tepikin, A.V., Sutton, R., Petersen, O.H. J. Biol. Chem. (2006)