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Gene Review:

Rfv1 - recovery from Friend virus 1

Mus musculus

Synonyms: Rfv-1

Britt, W.J. et al., Britt, W.J. et al., Dietz, M. et al., Miyazawa, M. et al., Chesebro, B. et al.

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Disease relevance of Rfv1

Using H-2 recombinant and mutant mice, the Rfv-1 gene influencing spontaneous recovery from Friend retrovirus (FV)-induced leukaemia was mapped in the D locus [1].
H-2D (Rfv-1) gene influence on recovery from Friend virus leukemia is mediated by nonleukemic cells of the spleen and bone marrow [2].

High impact information on Rfv1

This correlated with the Rfv-1, H-2D-linked influence on recovery from FV by these mice, and also appeared to explain the prominent effect of virus dose on recovery incidence [3].
The data suggest that regression is influenced by several genes, including those (Rfv-1, Rfv-2, Rfv-3) shown to affect recovery from leukemia in other systems [4].

Biological context of Rfv1

Rfv-1 was determined to be in the H-2G or H-2D regions by testing of mice with recombinations both to the left and right of these regions [5].

Anatomical context of Rfv1

Thus, the H-2D (Rfv-1) influence on recovery appeared to operate via nonleukemic cells of the spleen and bone marrow rather than via leukemic cells [2].

References

Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia. Miyazawa, M., Nishio, J., Wehrly, K., Jay, G., Melvold, R.W., Chesebro, B. Eur. J. Immunogenet. (1992) [Pubmed]
H-2D (Rfv-1) gene influence on recovery from Friend virus leukemia is mediated by nonleukemic cells of the spleen and bone marrow. Britt, W.J., Chesebro, B. J. Exp. Med. (1980) [Pubmed]
H-2D control of recovery from Friend virus leukemia: H-2D region influences the kinetics of the T lymphocyte response to Friend virus. Britt, W.J., Chesebro, B. J. Exp. Med. (1983) [Pubmed]
Spontaneous regression of Friend-virus-induced erythroleukemia. VII. The genetic control of regression. Dietz, M., Fouchey, S., Furmanski, P. Int. J. Cancer (1981) [Pubmed]
Rfv-1 and Rfv-2, two H-2-associated genes that influence recovery from Friend leukemia virus-induced splenomegaly. Chesebro, B., Wehrly, K. J. Immunol. (1978) [Pubmed]

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