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Gene Review

Rfv3  -  recovery from Friend virus 3

Mus musculus

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Disease relevance of Rfv3


High impact information on Rfv3

  • A single genetic locus, Rfv-3, influenced Friend virus (FV) viremia, loss of FV-induced cell-surface antigens from leukemia cells, and generation of anti-FV antibodies [5].
  • Specific major histocompatibility complex (MHC) class I and II alleles are necessary for recovery, as is a non-MHC gene, Rfv-3, which controls virus-specific antibody responses [6].
  • The Rfv-3 gene appeared to act by controlling anti-Friend virus antibody production [4].
  • In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia [3].
  • The Rfv-3 gene was found to influence the level of Friend leukemia virus production in spleens of leukemic mice later than 30 days after virus inoculation [4].

Biological context of Rfv3


Anatomical context of Rfv3

  • Potential candidate genes for Rfv3 are several genes expressed in cells of the immune system and previously mapped to the same region, including a T-cell antigen gene, Ly6, and three cytokine receptor genes, IL2rb, IL3rb1, and IL3rb2 [1].

Regulatory relationships of Rfv3

  • Microsatellite-based linkage analysis demonstrated that a non-major histocompatibility complex gene on chromosome 15 regulates long-term survival and is located in the same region as the Rfv3 gene [7].

Other interactions of Rfv3

  • The data suggest that regression is influenced by several genes, including those (Rfv-1, Rfv-2, Rfv-3) shown to affect recovery from leukemia in other systems [8].

Analytical, diagnostic and therapeutic context of Rfv3

  • This H-2 effect was observed not only in mice having heterozygous C57BL/10 X A background genes, including Rfv-3r/s, but also was apparent in mice having homozygous A-strain background genes, including Rfv-3s/s. Therefore, the Rfv-3 gene did not appear to convey resistance to FV-induced immunosuppression [9].


  1. Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus. Hasenkrug, K.J., Valenzuela, A., Letts, V.A., Nishio, J., Chesebro, B., Frankel, W.N. J. Virol. (1995) [Pubmed]
  2. Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15. Super, H.J., Hasenkrug, K.J., Simmons, S., Brooks, D.M., Konzek, R., Sarge, K.D., Morimoto, R.I., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Frankel, W., Chesebro, B. J. Virol. (1999) [Pubmed]
  3. Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Chesebro, B., Wehrly, K. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  4. Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. Chesebro, B., Wehrly, K., Doig, D., Nishio, J. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  5. Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production. Doig, D., Chesebro, B. J. Exp. Med. (1979) [Pubmed]
  6. Immunity to retroviral infection: the Friend virus model. Hasenkrug, K.J., Chesebro, B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Genetic regulation of long-term nonprogression in E-55+ murine leukemia virus infection in mice. Panoutsakopoulou, V., Hunter, K., Sieck, T.G., Blankenhorn, E.P., Blank, K.J. J. Virol. (1999) [Pubmed]
  8. Spontaneous regression of Friend-virus-induced erythroleukemia. VII. The genetic control of regression. Dietz, M., Fouchey, S., Furmanski, P. Int. J. Cancer (1981) [Pubmed]
  9. Influence of the murine MHC (H-2) on Friend leukemia virus-induced immunosuppression. Morrison, R.P., Nishio, J., Chesebro, B. J. Exp. Med. (1986) [Pubmed]
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