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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Recombination, Genetic

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Disease relevance of Recombination, Genetic

  • The recA protein, which is essential for genetic recombination in E. coli, promotes the homologous pairing of double-stranded DNA and linear single-stranded DNA, thereby forming a three-stranded joint molecule called a D loop [1].
  • An analyses of the RCCX structures in 22 salt-losing, congenital adrenal hyperplasia patients revealed a significant increase in the monomodular structure with a long C4 gene linked to the pseudogene CYP21A, and bimodular structures with two CYP21A, which are likely generated by recombinations between heterozygous RCCX length variants [2].
  • The beta protein of bacteriophage lambda acts in homologous genetic recombination by catalyzing the annealing of complementary single-stranded DNA produced by the lambda exonuclease [3].
  • Applying a recently developed PCR method, we have been able to detect the most commonly occurring illegitimate recombinations between alpha-chain switch region (S alpha) and c-myc in preneoplastic B cells residing in mesenteric oil granuloma (OG) tissues 7-30 days postpristane [4].
  • To initially determine the effect that base-pair mismatch has on homologous recombination in mammalian cells, we have studied genetic recombination between thymidine kinase (tk) gene sequences from herpes simplex virus 1 and 2 [5].

High impact information on Recombination, Genetic


Chemical compound and disease context of Recombination, Genetic


Biological context of Recombination, Genetic


Anatomical context of Recombination, Genetic


Associations of Recombination, Genetic with chemical compounds


Gene context of Recombination, Genetic


Analytical, diagnostic and therapeutic context of Recombination, Genetic


  1. Homologous pairing in genetic recombination: recA protein makes joint molecules of gapped circular DNA and closed circular DNA. Cunningham, R.P., DasGupta, C., Shibata, T., Radding, C.M. Cell (1980) [Pubmed]
  2. Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP-C4-CYP21-TNX (RCCX) modules in caucasians. The load of RCCX genetic diversity on major histocompatibility complex-associated disease. Blanchong, C.A., Zhou, B., Rupert, K.L., Chung, E.K., Jones, K.N., Sotos, J.F., Zipf, W.B., Rennebohm, R.M., Yung Yu, C. J. Exp. Med. (2000) [Pubmed]
  3. Rings and filaments of beta protein from bacteriophage lambda suggest a superfamily of recombination proteins. Passy, S.I., Yu, X., Li, Z., Radding, C.M., Egelman, E.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells. Müller, J.R., Potter, M., Janz, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Differential effects of base-pair mismatch on intrachromosomal versus extrachromosomal recombination in mouse cells. Waldman, A.S., Liskay, R.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  6. Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications. Nathenson, S.G., Geliebter, J., Pfaffenbach, G.M., Zeff, R.A. Annu. Rev. Immunol. (1986) [Pubmed]
  7. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Modrich, P., Lahue, R. Annu. Rev. Biochem. (1996) [Pubmed]
  8. Nonhomologous RNA recombination in a cell-free system: evidence for a transesterification mechanism guided by secondary structure. Chetverin, A.B., Chetverina, H.V., Demidenko, A.A., Ugarov, V.I. Cell (1997) [Pubmed]
  9. DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Sung, P., Robberson, D.L. Cell (1995) [Pubmed]
  10. The Sjögren-Larsson syndrome gene is close to D17S805 as determined by linkage analysis and allelic association. Pigg, M., Jagell, S., Sillén, A., Weissenbach, J., Gustavson, K.H., Wadelius, C. Nat. Genet. (1994) [Pubmed]
  11. Expression of the Escherichia coli dam methylase in Saccharomyces cerevisiae: effect of in vivo adenine methylation on genetic recombination and mutation. Hoekstra, M.F., Malone, R.E. Mol. Cell. Biol. (1985) [Pubmed]
  12. Action of ethyl and methyl methane sulfonates on DNA injection and genetic recombination in T7 bacteriophage. Karska-Wysocki, B., Mamet-Bratley, M.D., Verly, W.G. J. Virol. (1976) [Pubmed]
  13. Molecular evolution of the Escherichia coli chromosome. I. Analysis of structure and natural variation in a previously uncharacterized region between trp and tonB. Stoltzfus, A., Leslie, J.F., Milkman, R. Genetics (1988) [Pubmed]
  14. High-frequency homologous genetic recombination of an arterivirus, lactate dehydrogenase-elevating virus, in mice and evolution of neuropathogenic variants. Li, K., Chen, Z., Plagemann, P. Virology (1999) [Pubmed]
  15. Effect of deoxyribonucleic acid replication inhibitors on bacterial recombination. Canosi, U., Siccardi, A.G., Falaschi, A., Mazza, G. J. Bacteriol. (1976) [Pubmed]
  16. Holliday junction cleavage by yeast Rad1 protein. Habraken, Y., Sung, P., Prakash, L., Prakash, S. Nature (1994) [Pubmed]
  17. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. White, P.C., Speiser, P.W. Endocr. Rev. (2000) [Pubmed]
  18. Mismatch repair: mechanisms and relationship to cancer susceptibility. Kolodner, R.D. Trends Biochem. Sci. (1995) [Pubmed]
  19. RecQ family helicases: roles in cancer and aging. Karow, J.K., Wu, L., Hickson, I.D. Curr. Opin. Genet. Dev. (2000) [Pubmed]
  20. Progressive myoclonus epilepsy EPM1 locus maps to a 175-kb interval in distal 21q. Virtaneva, K., Miao, J., Träskelin, A.L., Stone, N., Warrington, J.A., Weissenbach, J., Myers, R.M., Cox, D.R., Sistonen, P., de la Chapelle, A. Am. J. Hum. Genet. (1996) [Pubmed]
  21. Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Janz, S., Müller, J., Shaughnessy, J., Potter, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice. Müller, J.R., Jones, G.M., Janz, S., Potter, M. Blood (1997) [Pubmed]
  23. Nonhomologous recombination at sites within the mouse JH-C delta locus accompanies C mu deletion and switch to immunoglobulin D secretion. Owens, J.D., Finkelman, F.D., Mountz, J.D., Mushinski, J.F. Mol. Cell. Biol. (1991) [Pubmed]
  24. Regulation of BMP7 expression during kidney development. Godin, R.E., Takaesu, N.T., Robertson, E.J., Dudley, A.T. Development (1998) [Pubmed]
  25. BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development. Bei, M., Kratochwil, K., Maas, R.L. Development (2000) [Pubmed]
  26. Regression of mouse mammary gland anlagen in recombinants of Tfm and wild-type tissues: testosterone acts via the mesenchyme. Drews, U., Drews, U. Cell (1977) [Pubmed]
  27. Induction of mitotic recombination in yeast by starvation for thymine nucleotides. Kunz, B.A., Barclay, B.J., Game, J.C., Little, J.G., Haynes, R.H. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  28. Structural effects of substitutions on the p21 proteins. Pincus, M.R., Brandt-Rauf, P.W. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  29. Primary structure of the RAD52 gene in Saccharomyces cerevisiae. Adzuma, K., Ogawa, T., Ogawa, H. Mol. Cell. Biol. (1984) [Pubmed]
  30. Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells. Ayusawa, D., Koyama, H., Shimizu, K., Kaneda, S., Takeishi, K., Seno, T. Mol. Cell. Biol. (1986) [Pubmed]
  31. Genetic mapping of the 21-hydroxylase-deficiency gene within the HLA linkage group. Levine, L.S., Zachmann, M., New, M.I., Prader, A., Pollack, M.S., O'Neill, G.J., Yang, S.Y., Oberfield, S.E., Dupont, B. N. Engl. J. Med. (1978) [Pubmed]
  32. DNA strand annealing is promoted by the yeast Rad52 protein. Mortensen, U.H., Bendixen, C., Sunjevaric, I., Rothstein, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  33. A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity. Czarny-Ratajczak, M., Lohiniva, J., Rogala, P., Kozlowski, K., Perälä, M., Carter, L., Spector, T.D., Kolodziej, L., Seppänen, U., Glazar, R., Królewski, J., Latos-Bielenska, A., Ala-Kokko, L. Am. J. Hum. Genet. (2001) [Pubmed]
  34. Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. Studamire, B., Price, G., Sugawara, N., Haber, J.E., Alani, E. Mol. Cell. Biol. (1999) [Pubmed]
  35. Novel recombinations in the maize mitochondrial genome produce a unique transcriptional unit in the Texas male-sterile cytoplasm. Dewey, R.E., Levings, C.S., Timothy, D.H. Cell (1986) [Pubmed]
  36. Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells. Feddersen, R.M., Van Ness, B.G. Mol. Cell. Biol. (1990) [Pubmed]
  37. Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. Vaahtokari, A., Vainio, S., Thesleff, I. Development (1991) [Pubmed]
  38. Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Lumsden, A.G. Development (1988) [Pubmed]
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