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Gene Review:

Ssbp - signal sequence binding protein

Mus musculus

This record was discontinued.

Tang, X. et al., Plaisance, S. et al.

Plaisance, Vanden Berghe, Boone, Fiers, Haegeman,

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High impact information on Ssbp

Analysis by electrophoretic mobility shift assays (EMSA) of the different proteins associated with the kappaB sequence of the interleukin-6 (IL-6) promoter (IL6-kappaB) allowed us to detect a specific complex formed with the recombination signal sequence binding protein Jkappa (RBP-Jkappa) [1].
The transcription factor KBF2 has been characterized as a factor that binds to the NFkB site of mouse major histocompatibility complex (MHC) class I genes and its amino acid sequence has been shwn to be identical to those of members of the recombination signal-sequence binding protein (RBP-Jk) family [2].

References

Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor. Plaisance, S., Vanden Berghe, W., Boone, E., Fiers, W., Haegeman, G. Mol. Cell. Biol. (1997) [Pubmed]
Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization. Tang, X., Saito-Ohara, F., Song, J., Koga, C., Ugai, H., Murakami, H., Ikeuchi, T., Yokoyama, K.K. Jpn. J. Hum. Genet. (1997) [Pubmed]

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