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Gene Review:

fdxB - ferredoxin

Nostoc sp. PCC 7120

Hase, T. et al., Schmitz, S. et al., Schrautemeier, B. et al.

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Disease relevance of fdxB

Sequence comparison of the heterocyst-type ferredoxin (FdxH) from Anabaena 7120 and type-1 ferredoxins (PetF) from the same organism and other cyanobacteria revealed a group of positively charged residues characteristic for FdxH [1].
This finding provides a structural basis for explaining the different chemical and functional properties of Nostoc strain MAC ferredoxin II reported in a previous paper (Hutson et al. (1978) Biochem. J. 172, 465-477) [2].
Comparing these sequences with those of ferredoxins from Chlorogloeopsis fritschii and Synechocystis 6714, which are also capable of growing under both conditions, showed that Nostoc strain MAC ferredoxin II had unique amino acids around the [2Fe-2S] cluster [2].

High impact information on fdxB

An fdxB-type gene encoding a 2[4Fe-4S] ferredoxin not previously identified in cyanobacteria is located immediately downstream of fdxH in P. boryanum [3].
Exchange of lysines 10 and 11 of FdxH for the corresponding residues of PetF (glutamate 10 and alanine 11) resulted in a ferredoxin with greatly decreased affinity to nitrogenase [1].

References

Evidence from directed mutagenesis that positively charged amino acids are necessary for interaction of nitrogenase with the [2Fe-2S] heterocyst ferredoxin (FdxH) from the cyanobacterium Anabaena sp., PCC7120. Schmitz, S., Schrautemeier, B., Böhme, H. Mol. Gen. Genet. (1993) [Pubmed]
Amino acid sequences of Nostoc strain MAC ferredoxins I and II. Hase, T., Matsubara, H., Hutber, G.N., Rogers, L.J. J. Biochem. (1982) [Pubmed]
Characterization of the genome region encoding an fdxH-type ferredoxin and a new 2[4Fe-4S] ferredoxin from the nonheterocystous, nitrogen-fixing cyanobacterium Plectonema boryanum PCC 73110. Schrautemeier, B., Cassing, A., Böhme, H. J. Bacteriol. (1994) [Pubmed]

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