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Gene Review:

H2-Q11 - histocompatibility 2, Q region locus 11

Mus musculus

Synonyms: Qa-11, Qa11

van de Meugheuvel, W. et al., Soloski, M.J. et al.

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High impact information on H2-Q11

Immunochemical analysis has shown that the Qa-11 Ag is expressed on class I molecules encoded by the Q7 gene from both C57BL/10 (Q7b) and BALB/c (Q7d), but not on the protein product of the Q9 gene isolated from the C57BL/10 strain (Q9b) [1].
To elucidate the molecular basis of this apparent paradox, we examined the expression of Qa-11 on products of transfected Q-region class I genes [1].
This paradox could be explained by a separate Qa-11 region between Qa-2 and Tla [2].
A new antigen, Qa-11, is detected as a 40,000 dalton band in the SDS-PAGE of immunoprecipitates of radiolabeled lymphocyte membrane preparations [2].

Other interactions of H2-Q11

Tests with recombinant inbred strains and with H-3 congenic strains show that, in addition to the Tla region, a gene linked to or identical with the beta 2-microglobulin-b-allele is required for the expression of Qa-11 as well [2].

References

Molecular basis of Qa-11 antigen and paradoxical Qa-gene expression in an H-2 recombinant. Soloski, M.J., Oudshoorn-Snoek, M., Einhorn, G., Demant, P. J. Immunol. (1989) [Pubmed]
A new Tla region antigen Qa-11, similar to Qa-2 and associated with B-type beta 2-microglobulin. van de Meugheuvel, W., van Seventer, G., Demant, P. J. Immunol. (1985) [Pubmed]

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