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Gene Review:

Idd11 - insulin dependent diabetes susceptibility 11

Mus musculus

Rolf, J. et al., Brodnicki, T.C. et al., Brodnicki, T.C. et al.

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High impact information on Idd11

Congenic nonobese diabetic mouse strains fail to confirm linkage of a marginal zone B lymphocyte phenotype to the Idd11 locus on chromosome 4 [1].
Using an F2(B6 x NOD) cross in a genome-wide scan, we map the control of this trait to a region on chromosome 4 (logarithm of odds score, 4.4) which includes the Idd11 and Idd9 diabetes susceptibility loci, supporting the hypothesis that this B cell trait is related to the development of diabetes in the NOD mouse [2].
The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11 [2].
These results define a new distal boundary for Idd11 and eliminate the Slc9a1 gene as a candidate [3].

Biological context of Idd11

We previously located a NOD diabetes susceptibility locus, designated Idd11, on mouse Chromosome (Chr) 4 by analyzing diabetic backcross mice produced after crossing NOD/Lt with the nondiabetic resistant strain C57BL/6 (B6) strain [3].

References

Congenic nonobese diabetic mouse strains fail to confirm linkage of a marginal zone B lymphocyte phenotype to the Idd11 locus on chromosome 4. Brodnicki, T.C., O'Donnell, K., Quirk, F., Tarlinton, D.M. J. Immunol. (2006) [Pubmed]
The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11. Rolf, J., Motta, V., Duarte, N., Lundholm, M., Berntman, E., Bergman, M.L., Sorokin, L., Cardell, S.L., Holmberg, D. J. Immunol. (2005) [Pubmed]
Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene. Brodnicki, T.C., McClive, P., Couper, S., Morahan, G. Immunogenetics (2000) [Pubmed]

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