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Gene Review

Idd9  -  insulin dependent diabetes susceptibility 9

Mus musculus

Synonyms: Idd-9
 
 
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Disease relevance of Idd9

 

High impact information on Idd9

  • Evidence for the existence of a gene only influencing diabetes, Idd9 on mouse chromosome 4, is provided here by the development of a novel congenic mouse strain, NOD.B10 Idd9 [2].
  • This enhanced engraftment potential maps to the insulin-dependent diabetes locus 9 (Idd9) locus, and as such the tumor necrosis factor (TNF) receptor family as well as ski/sno genes may be involved in the mechanism underlying the autonomy of NOD HSCs [3].
  • Finally, we demonstrate that the protective region on chromosome 4 that controls T1D in TNF-alpha-Idd9 mice is restricted to the Idd9.1 region [4].
  • Congenic strains on both the NOD and NOR backgrounds confirmed the roles of Idd4 and Idd9 in CY-T1D susceptibility and revealed the contribution of a third locus, Idd5 [5].
  • In this study we show by genetic linkage analysis of (NOD x NOR) x NOD backcross mice that progression to severe islet inflammation after CY treatment was controlled by the Idd4 and Idd9 loci [5].
 

Anatomical context of Idd9

  • In contrast, resistance alleles in Idd9 mice do not prevent the accumulation of islet Ag-specific CD8+ and CD4+ T cells in the pancreatic lymph nodes, indicating that tolerance occurs at a later checkpoint [6].
  • Using an F2(B6 x NOD) cross in a genome-wide scan, we map the control of this trait to a region on chromosome 4 (logarithm of odds score, 4.4) which includes the Idd11 and Idd9 diabetes susceptibility loci, supporting the hypothesis that this B cell trait is related to the development of diabetes in the NOD mouse [7].
 

Other interactions of Idd9

  • Dominant traits, detectable only in the F2 cross, were encoded by Chr 4 (Idd9) and two newly mapped loci on Chr 13 (Idd14) and 5 (Idd15) [8].
  • In the present study, Cd30 was mapped to a 5.6-cM interval on chromosome 4 containing the type 1 diabetes susceptibility locus Idd9 [9].
 

Analytical, diagnostic and therapeutic context of Idd9

  • Islet allograft tolerance could not be induced in diabetes-resistant NOD.B10 Idd5 and NOD.B10 Idd9 mice [10].

References

  1. Insulin-dependent diabetes loci Idd5 and Idd9 increase sensitivity to experimental autoimmune encephalomyelitis. Mayo, S., Kohler, W., Kumar, V., Quinn, A. Clin. Immunol. (2006) [Pubmed]
  2. The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. Lyons, P.A., Hancock, W.W., Denny, P., Lord, C.J., Hill, N.J., Armitage, N., Siegmund, T., Todd, J.A., Phillips, M.S., Hess, J.F., Chen, S.L., Fischer, P.A., Peterson, L.B., Wicker, L.S. Immunity (2000) [Pubmed]
  3. Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Chilton, P.M., Rezzoug, F., Ratajczak, M.Z., Fugier-Vivier, I., Ratajczak, J., Kucia, M., Huang, Y., Tanner, M.K., Ildstad, S.T. Blood (2005) [Pubmed]
  4. A 20-Mb Region of Chromosome 4 Controls TNF-{alpha}-Mediated CD8+ T Cell Aggression Toward beta Cells in Type 1 Diabetes. Chamberlain, G., W??llberg, M., Rainbow, D., Hunter, K., Wicker, L.S., Green, E.A. J. Immunol. (2006) [Pubmed]
  5. Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. Ivakine, E.A., Fox, C.J., Paterson, A.D., Mortin-Toth, S.M., Canty, A., Walton, D.S., Aleksa, K., Ito, S., Danska, J.S. J. Immunol. (2005) [Pubmed]
  6. CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles. Martinez, X., Kreuwel, H.T., Redmond, W.L., Trenney, R., Hunter, K., Rosen, H., Sarvetnick, N., Wicker, L.S., Sherman, L.A. J. Immunol. (2005) [Pubmed]
  7. The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11. Rolf, J., Motta, V., Duarte, N., Lundholm, M., Berntman, E., Bergman, M.L., Sorokin, L., Cardell, S.L., Holmberg, D. J. Immunol. (2005) [Pubmed]
  8. Crosses of NOD mice with the related NON strain. A polygenic model for IDDM. McAleer, M.A., Reifsnyder, P., Palmer, S.M., Prochazka, M., Love, J.M., Copeman, J.B., Powell, E.E., Rodrigues, N.R., Prins, J.B., Serreze, D.V. Diabetes (1995) [Pubmed]
  9. Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2. Siegmund, T., Armitage, N., Wicker, L.S., Peterson, L.B., Todd, J.A., Lyons, P.A. Diabetes (2000) [Pubmed]
  10. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Pearson, T., Weiser, P., Markees, T.G., Serreze, D.V., Wicker, L.S., Peterson, L.B., Cumisky, A.M., Shultz, L.D., Mordes, J.P., Rossini, A.A., Greiner, D.L. Diabetes (2004) [Pubmed]
 
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