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Gene Review

nuiA  -  sugar-non-specific nuclease inhibitor

Nostoc sp. PCC 7120

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Disease relevance of nuiA


Anatomical context of nuiA

  • With all constructs, tandem expression of nucA and nuiA results in aggregation and inclusion body formation of NucA, independent of the order of the genes, the relative expression of the two proteins and the temperature applied during expression [2].


  1. The nuiA gene from Anabaena sp. encoding an inhibitor of the NucA sugar-non-specific nuclease. Muro-Pastor, A.M., Herrero, A., Flores, E. J. Mol. Biol. (1997) [Pubmed]
  2. Genetic engineering of Escherichia coli to produce a 1:1 complex of the anabaena sp. PCC 7120 nuclease NucA and its inhibitor NuiA. Korn, C., Meiss, G., Gast, F., Gimadutdinow, O., Urbanke, C., Pingoud, A. Gene (2000) [Pubmed]
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