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Gene Review:

Mov15 - Moloney leukemia virus 15

Mus musculus

Synonyms: Mov-15

Harbers, K. et al., Yen, C.H. et al., Soriano, P. et al., Harbers, K. et al.

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Disease relevance of Mov15

The pseudoautosomal region of the Mov15 mouse strain is marked by a Moloney murine leukemia provirus [1].

High impact information on Mov15

We now show that the transgenic mouse strain, Mov-15, contains a single Moloney murine leukaemia virus (M-MuLV) genome in its germline, and genetic evidence indicates that the provirus is integrated into the pseudoautosomal region of the sex chromosome [2].
Mice heterozygous at two pseudoautosomal alleles, the steroid sulfatase gene and the Mov-15 provirus marker, were crossed [3].
Sequences similar to Mov15 lie close to the vector end of the clone, while the other end contains a telomere array that appears to be interstitial within the PAR, suggesting that the insert represents a proximal portion of the PAR [4].

References

Structure and chromosomal mapping of a highly polymorphic repetitive DNA sequence from the pseudoautosomal region of the mouse sex chromosomes. Harbers, K., Francke, U., Soriano, P., Jaenisch, R., Müller, U. Cytogenet. Cell Genet. (1990) [Pubmed]
High frequency of unequal recombination in pseudoautosomal region shown by proviral insertion in transgenic mouse. Harbers, K., Soriano, P., Müller, U., Jaenisch, R. Nature (1986) [Pubmed]
High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis. Soriano, P., Keitges, E.A., Schorderet, D.F., Harbers, K., Gartler, S.M., Jaenisch, R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
Characterization of a Mus spretus YAC that maps to the pseudoautosomal region. Yen, C.H., Elliott, R.W. Genomics (1997) [Pubmed]

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