Gene Review:
Lmb3 - lupus in MRL and B6 F2 cross, QTL 3
Mus musculus
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Disease relevance of Lmb3
- The centromeric region of chromosome 7 was identified as a lupus susceptibility locus in MRL/Fas(lpr) mice as Lmb3 [1].
- The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression [1].
- Detailed analysis of these animals showed that Lmb3 enhances and accelerates several characteristics of lupus, including autoantibody production, kidney disease, and T cell activation, as well as accumulation of CD4(-)CD8(-) double-negative T cells, the latter a feature of Fas-deficient mice [1].
Biological context of Lmb3
- These findings confirm the role of Lmb3 in lupus susceptibility, as a modifier of Fas(lpr) phenotype, and illustrate the importance of epistatic interaction between genetic loci in the etiology of lupus [1].
References
- The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. Kong, P.L., Morel, L., Croker, B.P., Craft, J. J. Immunol. (2004) [Pubmed]
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