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Coro1a  -  coronin, actin binding protein 1A

Mus musculus

Synonyms: Clabp, Clipin-A, Coro1, Coronin-1A, Coronin-like protein A, ...
 
 
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Disease relevance of Coro1a

  • Interestingly, whereas coronin-1 also accumulates at the sites of actin remodeling associated with Salmonella invasion, TAT-WD had no effect on this process [1].
  • Western and northern blotting showed that coronin 1A was predominantly expressed in solid lymphomas [2].
  • Three noncontiguous p57-binding sites were located within the poliovirus 5' nontranslated region, between nt 70 and 288, and 443 and 539 (domain V), and 630 and 730 [3].
  • Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin [4].
  • Whereas p57 was purified from human erythrocytes, p65 was identified using polyclonal anti-p57 antibodies on a human melanoma cell line resistant to complement lysis [5].
 

High impact information on Coro1a

  • This protein, termed TACO, represents a component of the phagosome coat that is normally released prior to phagosome fusion with or maturation into lysosomes [6].
  • In macrophages lacking TACO, mycobacteria were readily transported to lysosomes followed by their degradation [6].
  • Thus, by entering host cells at cholesterol-rich domains of the plasma membrane, mycobacteria may ensure their subsequent intracellular survival in TACO-coated phagosomes [7].
  • Mice lacking both p21 and p57 fail to form myotubes, display increased proliferation and apoptotic rates of myoblasts, and display endoreplication in residual myotubes [8].
  • Expression of myogenin, p21, and p57 is parallel but independent, and in response to differentiation signals, these proteins are coordinately regulated to trigger both cell-cycle exit and a dependent muscle-specific program of gene expression to initiate myoblast terminal differentiation and muscle formation [8].
 

Chemical compound and disease context of Coro1a

  • The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region [3].
 

Biological context of Coro1a

 

Anatomical context of Coro1a

  • Here, we describe that coronin 1 molecules are coiled coil-mediated homotrimeric complexes, which associate with the plasma membrane and with the cytoskeleton via two distinct domains [11].
  • Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules [11].
  • Here, we characterize Coronin-1 gene and protein expression in mouse embryonic and adult T lymphocytes [12].
  • Subcellular localization analysis indicates that Coronin-1 is in equilibrium between the cytosol and the cell cortex, where it accumulates in F-actin-rich membrane protrusions induced by polarized activation of TCR-CD3-stimulated T cells [12].
  • The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes [13].
 

Associations of Coro1a with chemical compounds

  • Cholesterol also mediated the phagosomal association of TACO, a coat protein that prevents degradation of mycobacteria in lysosomes [7].
  • In mouse mammary tumor cell lines (GR and Mm5MT) producing MuMTV the major p57 antigenic specificity resides in a large protein, which migrates in polyacrylamide gels as a doublet of 77,000 and 75,000 daltons (p 77/75) [14].
  • We previously identified, on normal or tumour cells, two membrane proteinases, p57 and p65, that cleave human C3, the third component of complement, thus regulating C3's biological properties [5].
  • Proliferation was analyzed comparing cells transfected with p21 and/or p57 ASO vs. cells transfected with scrambled ASO using a bromodeoxyuridine assay [15].
 

Other interactions of Coro1a

 

Analytical, diagnostic and therapeutic context of Coro1a

References

  1. Coronin-1 function is required for phagosome formation. Yan, M., Collins, R.F., Grinstein, S., Trimble, W.S. Mol. Biol. Cell (2005) [Pubmed]
  2. Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma. Yanagisawa, Y., Sato, Y., Asahi-Ozaki, Y., Ito, E., Honma, R., Imai, J., Kanno, T., Kano, M., Akiyama, H., Sata, T., Shinkai-Ouchi, F., Yamakawa, Y., Watanabe, S., Katano, H. J. Pathol. (2006) [Pubmed]
  3. The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region. Hellen, C.U., Pestova, T.V., Litterst, M., Wimmer, E. J. Virol. (1994) [Pubmed]
  4. Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin. Solomon, J.M., Leung, G.S., Isberg, R.R. Infect. Immun. (2003) [Pubmed]
  5. Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L. Jean, D., Hermann, J., Rodrigues-Lima, F., Barel, M., Balbo, M., Frade, R. Biochem. J. (1995) [Pubmed]
  6. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Ferrari, G., Langen, H., Naito, M., Pieters, J. Cell (1999) [Pubmed]
  7. Essential role for cholesterol in entry of mycobacteria into macrophages. Gatfield, J., Pieters, J. Science (2000) [Pubmed]
  8. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Zhang, P., Wong, C., Liu, D., Finegold, M., Harper, J.W., Elledge, S.J. Genes Dev. (1999) [Pubmed]
  9. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. Okumura, M., Kung, C., Wong, S., Rodgers, M., Thomas, M.L. DNA Cell Biol. (1998) [Pubmed]
  10. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. Nakamura, T., Takeuchi, K., Muraoka, S., Takezoe, H., Takahashi, N., Mori, N. J. Biol. Chem. (1999) [Pubmed]
  11. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Gatfield, J., Albrecht, I., Zanolari, B., Steinmetz, M.O., Pieters, J. Mol. Biol. Cell (2005) [Pubmed]
  12. Coronin-1 expression in T lymphocytes: insights into protein function during T cell development and activation. Nal, B., Carroll, P., Mohr, E., Verthuy, C., Da Silva, M.I., Gayet, O., Guo, X.J., He, H.T., Alcover, A., Ferrier, P. Int. Immunol. (2004) [Pubmed]
  13. The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Appleton, B.A., Wu, P., Wiesmann, C. Structure (2006) [Pubmed]
  14. Polyproteins related to the major core protein of mouse mammary tumor virus. Dickson, C., Atterwill, M. J. Virol. (1978) [Pubmed]
  15. Transfection of normal primary human skeletal myoblasts with p21 and p57 antisense oligonucleotides to improve their proliferation: a first step towards an alternative molecular therapy approach of Duchenne muscular dystrophy. Endesfelder, S., Bucher, S., Kliche, A., Reszka, R., Speer, A. J. Mol. Med. (2003) [Pubmed]
  16. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Föger, N., Rangell, L., Danilenko, D.M., Chan, A.C. Science (2006) [Pubmed]
  17. Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase. Didichenko, S.A., Segal, A.W., Thelen, M. FEBS Lett. (2000) [Pubmed]
  18. Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. Goode, B.L., Wong, J.J., Butty, A.C., Peter, M., McCormack, A.L., Yates, J.R., Drubin, D.G., Barnes, G. J. Cell Biol. (1999) [Pubmed]
  19. Maleyl-BSA and fucoidan induce expression of a set of early proteins in murine mononuclear phagocytes. Johnston, P.A., Jansen, M.M., Somers, S.D., Adams, D.O., Hamilton, T.A. J. Immunol. (1987) [Pubmed]
 
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