The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Eae2  -  experimental allergic encephalomyelitis...

Mus musculus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Eae2


High impact information on Eae2

  • Investigation of the CD4/CD8 T cell ratio in mice from the partially advanced intercross shows that this trait is linked to one of the Eae2 subloci through interactions with Eae3/Cia5 [2].
  • Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio [2].
  • Furthermore, the expression of CD86 on stimulated macrophages is linked to Eae2 [2].
  • We found that Eae2 consists of four Cia subloci (Cia26, Cia30, Cia31, and Cia32), of which two interacted with each other, conferring severe CIA [2].

Biological context of Eae2


  1. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Kuokkanen, S., Sundvall, M., Terwilliger, J.D., Tienari, P.J., Wikström, J., Holmdahl, R., Pettersson, U., Peltonen, L. Nat. Genet. (1996) [Pubmed]
  2. Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. Karlsson, J., Johannesson, M., Lindvall, T., Wernhoff, P., Holmdahl, R., Andersson, A. J. Immunol. (2005) [Pubmed]
  3. Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. Karlsson, J., Zhao, X., Lonskaya, I., Neptin, M., Holmdahl, R., Andersson, A. J. Immunol. (2003) [Pubmed]
WikiGenes - Universities