Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Eae2 - experimental allergic encephalomyelitis...

Mus musculus

Karlsson, J. et al., Karlsson, J. et al., Kuokkanen, S. et al.

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Disease relevance of Eae2

A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2 [1].
The Eae2 locus on mouse chromosome 15 controls the development of experimental autoimmune encephalomyelitis (EAE); however, in this study we show that it also controls collagen-induced arthritis (CIA) [2].

High impact information on Eae2

Investigation of the CD4/CD8 T cell ratio in mice from the partially advanced intercross shows that this trait is linked to one of the Eae2 subloci through interactions with Eae3/Cia5 [2].
Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio [2].
Furthermore, the expression of CD86 on stimulated macrophages is linked to Eae2 [2].
We found that Eae2 consists of four Cia subloci (Cia26, Cia30, Cia31, and Cia32), of which two interacted with each other, conferring severe CIA [2].

Biological context of Eae2

The quantitative trait locus on chromosome 15 partly overlapped with the Eae2 locus, previously identified in crosses between the B10.RIII and RIIIS/J mouse strains [3].

References

A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Kuokkanen, S., Sundvall, M., Terwilliger, J.D., Tienari, P.J., Wikström, J., Holmdahl, R., Pettersson, U., Peltonen, L. Nat. Genet. (1996) [Pubmed]
Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. Karlsson, J., Johannesson, M., Lindvall, T., Wernhoff, P., Holmdahl, R., Andersson, A. J. Immunol. (2005) [Pubmed]
Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. Karlsson, J., Zhao, X., Lonskaya, I., Neptin, M., Holmdahl, R., Andersson, A. J. Immunol. (2003) [Pubmed]

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