Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CHN2 - chimerin 2

Homo sapiens

Synonyms: ARHGAP3, BCH, Beta-chimaerin, Beta-chimerin, CHN2-3, ...

Leung, T. et al., Johnstone, C.N. et al., Nawashiro, H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CHN2

BCH inhibited the growth of C6 glioma cells in vitro and in vivo in a dose-dependent manner [1].

High impact information on CHN2

The cDNAs also encoded an additional N-terminal SH2 (Src homology 2) domain, probably derived from the beta-chimaerin gene by alternate splicing [2].
The SH2 domains of alpha- and beta-chimaerin thus represent a subset of SH2 domains [2].
With beta-chimaerin cDNA as a probe and using polymerase chain reaction, cDNAs from both human and rat cerebellum were isolated [2].
Three alternatively spliced ARHGAP8 transcripts were expressed in normal mammary gland and colon, which differed in the size of the BCH/Sec14p-like domain only [3].

References

L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Nawashiro, H., Otani, N., Shinomiya, N., Fukui, S., Ooigawa, H., Shima, K., Matsuo, H., Kanai, Y., Endou, H. Int. J. Cancer (2006) [Pubmed]
Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. Leung, T., How, B.E., Manser, E., Lim, L. J. Biol. Chem. (1994) [Pubmed]
ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers. Johnstone, C.N., Castellví-Bel, S., Chang, L.M., Bessa, X., Nakagawa, H., Harada, H., Sung, R.K., Piqué, J.M., Castells, A., Rustgi, A.K. Gene (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

chin-1	Caenorhabditis elegans
CHN2	Canis lupus familiaris
chn2	Danio rerio
CHN2	Gallus gallus
CHN2	Macaca mulatta
Chn2	Mus musculus
CHN2	Pan troglodytes
chn2	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.