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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Egln2  -  egl-9 family hypoxia-inducible factor 2

Mus musculus

Synonyms: 0610011A13Rik, C85656, Egl nine homolog 2, Falkor, HIF-PH1, ...
 
 
 
 
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Disease relevance of Egln2

  • The C-terminal domain of Falkor, isolated from the GSE library, has significant homology to a known human and rat cell growth regulator, SM-20, and to the C. elegans protein EGL-9, recently shown to modify the Hypoxia Inducible Factor-1alpha [1].
 

High impact information on Egln2

  • In this screen, expression of the C-terminal domain of Falkor conferred cells with resistance to cisplatin-induced growth arrest [1].
 

Biological context of Egln2

References

  1. Falkor, a novel cell growth regulator isolated by a functional genetic screen. Erez, N., Milyavsky, M., Goldfinger, N., Peles, E., Gudkov, A.V., Rotter, V. Oncogene (2002) [Pubmed]
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