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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Egln2  -  egl-9 family hypoxia-inducible factor 2

Rattus norvegicus

Synonyms: Egl nine homolog 2, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, HPH-3, ...
 
 
 
 
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Disease relevance of Egln2

  • PHD2 mRNA and protein expression levels were upregulated after 3 d of hypoxia; PHD1 protein declined after 14 d of hypoxia without significant mRNA changes [1].
  • Hypoxia-inducible factor (HIF)-alpha subunits (HIF-1alpha, HIF-2alpha and HIF-3alpha), which play a pivotal role during the development of hypoxia-induced pulmonary hypertension (HPH), are regulated through post-translational hydroxylation by their three prolyl hydroxylase domain-containing proteins (PHD1, PHD2 and PHD3) [1].

References

  1. Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension. Chen, Y.R., Dai, A.G., Hu, R.C., Jiang, Y.L. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
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