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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DDX19B  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B

Homo sapiens

Synonyms: ATP-dependent RNA helicase DDX19B, DBP5, DDX19, DEAD box RNA helicase DEAD5, DEAD box protein 19B, ...
 
 
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High impact information on DDX19B

  • As properly processed mRNPs translocate through the pore, certain mRNP proteins are removed, probably through the enzymatic action of the DEAD-box helicase Dbp5, which binds to Nup159 and Gle1, components of the cytoplasmic filaments of the NPC [1].
  • Gle1 and the phosphoinositide IP6 activate Dbp5's ATPase activity in vitro and this could provide critical spatial regulation of Dbp5 activity in vivo [1].
 

Physical interactions of DDX19B

  • Using in vitro assays, we demonstrate that NUP214 decreases both the RNA binding and ATPase activities of DBP5 [2].

References

  1. Transport of messenger RNA from the nucleus to the cytoplasm. Cole, C.N., Scarcelli, J.J. Curr. Opin. Cell Biol. (2006) [Pubmed]
  2. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. von Moeller, H., Basquin, C., Conti, E. Nat. Struct. Mol. Biol. (2009) [Pubmed]
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