Gene Review:
NUP214 - nucleoporin 214kDa
Homo sapiens
Synonyms:
214 kDa nucleoporin, CAIN, CAN, D9S46E, KIAA0023, ...
- Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Graux, C., Cools, J., Melotte, C., Quentmeier, H., Ferrando, A., Levine, R., Vermeesch, J.R., Stul, M., Dutta, B., Boeckx, N., Bosly, A., Heimann, P., Uyttebroeck, A., Mentens, N., Somers, R., MacLeod, R.A., Drexler, H.G., Look, A.T., Gilliland, D.G., Michaux, L., Vandenberghe, P., Wlodarska, I., Marynen, P., Hagemeijer, A. Nat. Genet. (2004)
- Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. Zolotukhin, A.S., Felber, B.K. J. Virol. (1999)
- DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification. Garçon, L., Libura, M., Delabesse, E., Valensi, F., Asnafi, V., Berger, C., Schmitt, C., Leblanc, T., Buzyn, A., Macintyre, E. Leukemia (2005)
- The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. Li, M., Makkinje, A., Damuni, Z. J. Biol. Chem. (1996)
- Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nakamura, T., Largaespada, D.A., Lee, M.P., Johnson, L.A., Ohyashiki, K., Toyama, K., Chen, S.J., Willman, C.L., Chen, I.M., Feinberg, A.P., Jenkins, N.A., Copeland, N.G., Shaughnessy, J.D. Nat. Genet. (1996)
- Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Xu, L., Kang, Y., Cöl, S., Massagué, J. Mol. Cell (2002)
- Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. Boer, J., Bonten-Surtel, J., Grosveld, G. Mol. Cell. Biol. (1998)
- Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32). De Keersmaecker, K., Graux, C., Odero, M.D., Mentens, N., Somers, R., Maertens, J., Wlodarska, I., Vandenberghe, P., Hagemeijer, A., Marynen, P., Cools, J. Blood (2005)
- Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export. Bernad, R., van der Velde, H., Fornerod, M., Pickersgill, H. Mol. Cell. Biol. (2004)
- RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Askjaer, P., Bachi, A., Wilm, M., Bischoff, F.R., Weeks, D.L., Ogniewski, V., Ohno, M., Niehrs, C., Kjems, J., Mattaj, I.W., Fornerod, M. Mol. Cell. Biol. (1999)
- The nucleoporin CAN/Nup214 binds to both the cytoplasmic and the nucleoplasmic sides of the nuclear pore complex in overexpressing cells. Boer, J.M., van Deursen, J.M., Croes, H.J., Fransen, J.A., Grosveld, G.C. Exp. Cell Res. (1997)
- Nucleoporin domain topology is linked to the transport status of the nuclear pore complex. Paulillo, S.M., Phillips, E.M., Köser, J., Sauder, U., Ullman, K.S., Powers, M.A., Fahrenkrog, B. J. Mol. Biol. (2005)
- Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls. Kozlovsky, N., Scarr, E., Dean, B., Agam, G. Schizophr. Res. (2006)
- Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. Bastos, R., Ribas de Pouplana, L., Enarson, M., Bodoor, K., Burke, B. J. Cell Biol. (1997)
- CRM1-dependent function of a cis-acting RNA export element. Popa, I., Harris, M.E., Donello, J.E., Hope, T.J. Mol. Cell. Biol. (2002)
- Changes in nucleoporin domain topology in response to chemical effectors. Paulillo, S.M., Powers, M.A., Ullman, K.S., Fahrenkrog, B. J. Mol. Biol. (2006)
- Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210. Favreau, C., Worman, H.J., Wozniak, R.W., Frappier, T., Courvalin, J.C. Biochemistry (1996)
- Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture. Harrap, K.R. Cancer Res. (1995)
- Nup214 is required for CRM1-dependent nuclear protein export in vivo. Hutten, S., Kehlenbach, R.H. Mol. Cell. Biol. (2006)
- CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Kasper, L.H., Brindle, P.K., Schnabel, C.A., Pritchard, C.E., Cleary, M.L., van Deursen, J.M. Mol. Cell. Biol. (1999)
- Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. Xu, L., Alarcón, C., Cöl, S., Massagué, J. J. Biol. Chem. (2003)
- A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. Kehlenbach, R.H., Dickmanns, A., Kehlenbach, A., Guan, T., Gerace, L. J. Cell Biol. (1999)
- The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. Katahira, J., Strässer, K., Podtelejnikov, A., Mann, M., Jung, J.U., Hurt, E. EMBO J. (1999)
- NUP214-ABL1 in adult T-ALL: the GMALL study group experience. Burmeister, T., G??kbuget, N., Reinhardt, R., Rieder, H., Hoelzer, D., Schwartz, S. Blood (2006)
- Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export. Saito, S., Miyaji-Yamaguchi, M., Nagata, K. Int. J. Cancer (2004)
- Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells. Fenstermaker, R.A., Ciesielski, M.J., Castiglia, G.J. Oncogene (1998)
- Is the Vroman effect of importance in the interaction of blood with artificial materials? Leonard, E.F., Vroman, L. Journal of biomaterials science. Polymer edition. (1991)