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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CHRM3  -  cholinergic receptor, muscarinic 3

Homo sapiens

Synonyms: EGBRS, HM3, Muscarinic acetylcholine receptor M3
 
 
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Disease relevance of CHRM3

  • Our conclusion is that the presence of muscarinic acetylcholine receptor M3 by immunostaining distinguishes normal glandular epithelium and low-grade carcinomas from poorly differentiated tumors, which suggests that its demonstration in vivo could be a useful tool in distinguishing grade of tumor clinically [1].
 

High impact information on CHRM3

  • CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians [2].
  • The muscarinic acetylcholine receptor subtype M3 (CHRM3) gene is expressed in islet beta-cells and has a role in stimulating insulin secretion; therefore, CHRM3 was analyzed as a candidate gene for type 2 diabetes in Pima Indians [2].

References

  1. Muscarinic M3 acetylcholine receptor immunostaining in paraffin-embedded normal and neoplastic prostatic gland tissue. Blanco, M., Robinson, M.J. Annals of diagnostic pathology. (2004) [Pubmed]
  2. CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians. Guo, Y., Traurig, M., Ma, L., Kobes, S., Harper, I., Infante, A.M., Bogardus, C., Baier, L.J., Prochazka, M. Diabetes (2006) [Pubmed]
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