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Gene Review

acvB  -  agrobacterium chromosomal virulence protein B

Agrobacterium fabrum str. C58

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Disease relevance of acvB

  • Although the majority of genes required for the transfer of T-DNA from Agrobacterium tumefaciens to plant nuclei are located on the Ti plasmid, some chromosomal genes, including the recently described acvB gene, are also required [1].

High impact information on acvB

  • The octopine-type Ti plasmid pTiA6 of Agrobacterium tumefaciens contains a gene homologous to the chromosomal virulence gene acvB [1].
  • Although the roles of the two homologous genes in tumorigenesis remain to be elucidated, strains lacking acvB and virJ (i) are proficient for induction of the vir regulon, (ii) are able to transfer their Ti plasmids by conjugation, and (iii) are resistant to plant wound extracts [1].
  • Homology search found no genes homologous to acvB, although it had some similarity to the open reading frame downstream of the virA gene on the Ti plasmid [2].
  • Introduction of the acvB gene into the mutant B119 strain complemented the avirulent phenotype of the strain [2].
  • A gene region containing the gusA fusion was sequenced, revealing five S. medicae genes: tcsA, tcrA, fsrR, lpiA and acvB [3].


  1. The octopine-type Ti plasmid pTiA6 of Agrobacterium tumefaciens contains a gene homologous to the chromosomal virulence gene acvB. Kalogeraki, V.S., Winans, S.C. J. Bacteriol. (1995) [Pubmed]
  2. Isolation and characterization of a new chromosomal virulence gene of Agrobacterium tumefaciens. Wirawan, I.G., Kang, H.W., Kojima, M. J. Bacteriol. (1993) [Pubmed]
  3. The Sinorhizobium medicae WSM419 lpiA gene is transcriptionally activated by FsrR and required to enhance survival in lethal acid conditions. Reeve, W.G., Br??u, L., Castelli, J., Garau, G., Sohlenkamp, C., Geiger, O., Dilworth, M.J., Glenn, A.R., Howieson, J.G., Tiwari, R.P. Microbiology (Reading, Engl.) (2006) [Pubmed]
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