Gene Review:
irx1b - iroquois homeobox 1b
Danio rerio
Synonyms:
SO:0000704, iro1, ziro1
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High impact information on irx1b
- We have identified a novel Iroquois (Iro) gene, iro7, in zebrafish. iro7 is expressed during gastrulation along with iro1 in a compartment of the dorsal ectoderm that includes the prospective midbrain-hindbrain domain, the adjacent neural crest and the trigeminal placodes in the epidermis [1].
Anatomical context of irx1b
- In addition, a knockdown of both iro1 and iro7 genes uncovered their essential roles in neural crest development and establishment of the isthmic organizer at the MHB [1].
- A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary [1].
Other interactions of irx1b
- The iro1 and iro7 expression domain is expanded in headless and masterblind mutants, which are characterized by exaggerated Wnt signaling [1].
References
- A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Itoh, M., Kudoh, T., Dedekian, M., Kim, C.H., Chitnis, A.B. Development (2002) [Pubmed]
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