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Gene Review

Crip3  -  cysteine-rich protein 3

Mus musculus

Synonyms: CRP-3, Cysteine-rich protein 3, TLP, TLP-A, TLP-B, ...
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High impact information on Crip3

  • Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity [1].
  • In both medullary and cortical thymic epithelial cell lines transduced with TLP, the protein localizes to the cytoplasm but does not appear to be strongly associated with actin [1].
  • TLP was identified as a gene product which is upregulated in a thymus in which selection of T cells is occurring (Rag(-/-) OT-1) compared to its expression in a thymus in which selection is blocked at the CD4+ CD8+ stage of T-cell development (Rag(-/-) Tap(-/-) OT-1) [1].
  • TLP has an apparent molecular mass of 23 kDa and exists as two isomers (TLP-A and TLP-B), which are generated by alternative splicing of the message [1].
  • We identified a LIM protein located on mouse chromosome 17 (m17TLP) and belonging to the family of the LIM-only proteins (LIMo) [2].

Biological context of Crip3


  1. Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity. Kirchner, J., Forbush, K.A., Bevan, M.J. Mol. Cell. Biol. (2001) [Pubmed]
  2. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. Casrouge, A., Veitia, R., Kirchner, J., Bevan, M.J., Kanellopoulos, J. Microbes Infect. (2004) [Pubmed]
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