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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PTPMT1  -  protein tyrosine phosphatase, mitochondrial 1

Homo sapiens

Synonyms: DUSP23, MOSP, PLIP, PNAS-129, PTEN-like phosphatase, ...
 
 
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High impact information on PTPMT1

  • Pagliarini et al (2005) recently identified a new mitochondrial specific protein tyrosine phosphatase, PTPMT1 [1].
  • A PTEN-like phosphatase with a novel substrate specificity [2].
  • PLIP is highly enriched in testis tissue and, similar to other PI phosphatases, exhibits poor activity against several proteinaceous substrates [2].
  • The responsible gene (MTM1) has been cloned; it encodes a phosphoinositide lipid phosphatase known as myotubularin that appears to be important in muscle maintenance [3].
  • Although white matter tracts within PKU brains are hypomyelinated, immunostaining and Western blot analyses revealed that these tracts contain abundant amounts of myelin markers, i.e. myelin basic protein (MBP), 2',3'-cyclic nucleotide 3'phosphohydrolase, and myelin/oligodendrocyte-specific protein (MOSP) [4].

References

  1. Firing up mitochondrial activities with PTPMT1. Boisclair, Y., Tremblay, M.L. Mol. Cell (2005) [Pubmed]
  2. A PTEN-like phosphatase with a novel substrate specificity. Pagliarini, D.J., Worby, C.A., Dixon, J.E. J. Biol. Chem. (2004) [Pubmed]
  3. X-linked myotubular and centronuclear myopathies. Pierson, C.R., Tomczak, K., Agrawal, P., Moghadaszadeh, B., Beggs, A.H. J. Neuropathol. Exp. Neurol. (2005) [Pubmed]
  4. Evidence for central nervous system glial cell plasticity in phenylketonuria. Dyer, C.A., Kendler, A., Philibotte, T., Gardiner, P., Cruz, J., Levy, H.L. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
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