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Gene Review: 

SLC25A26  -  solute carrier family 25 (S...

Homo sapiens

Synonyms: Mitochondrial S-adenosylmethionine transporter, S-adenosylmethionine mitochondrial carrier protein, SAMC, Solute carrier family 25 member 26
 
 
 
 
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High impact information on SLC25A26

  • The physiological role of SAMC is probably to exchange cytosolic SAM for mitochondrial S-adenosylhomocysteine [1].
  • SAMC was found to be expressed in all human tissues examined and was localized to the mitochondria [1].
  • Unlike the yeast orthologue, SAMC catalysed virtually only countertransport, exhibited a higher transport affinity for SAM and was strongly inhibited by tannic acid and Bromocresol Purple [1].

References

  1. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. Agrimi, G., Di Noia, M.A., Marobbio, C.M., Fiermonte, G., Lasorsa, F.M., Palmieri, F. Biochem. J. (2004) [Pubmed]
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