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Chemical Compound Review

AGN-PC-0CQV42     4-(bromomethyl)phenol

Synonyms: SureCN883392, KB-34850, CTK1H8687, KB-192720, AKOS000280406, ...
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Disease relevance of BROMOMETHYLPHENOL

  • All strains fermented glucose, sucrose, and fructose in purple broth base (Difco Laboratories) with bromocresol purple as indicator, although the atypical Pasteurella produced fermentation reactions that were barely perceptible [1].
  • Problems associated with plasma albumin estimation in nephrotic syndrome using the bromocresol green method [2].
  • Underestimation of albumin content by bromocresol green, induced by drug displacers and uremia [3].
  • Initial (10 min) fluxes and tissue accumulations (Ac) were measured in the absence and presence of 1-5 mM BCG (bromocresol green; competitor organic anion) [4].

High impact information on BROMOMETHYLPHENOL

  • We show here, however, that proton uptake, as indicated by bromocresol purple, and Schiff base deprotonation (380-nm absorption change) show different kinetics when the protein is solubilized in suitable detergents [5].
  • Bromocresol purple was added to the samples to detect pH changes in the aqueous environment due to changes in the protonation state of rhodopsin [6].
  • It can be differentiated from M. canis by the smaller size of its macroconidia, its failure to perforate hair in vitro, its poor growth and sporulation on bromocresol purple casein dextrose agar, and its incompatibility with Nannizzia otae, the telemorph of M. canis [7].
  • In this study, the "pH memory" is explored by comparing the extent of protonation of sulfonephthalein probe molecules, bromophenol blue, bromocresol green, and chlorophenol red, in aqueous solution in the pH range of 3.4-6.0 and in the resulting freeze-dried amorphous matrix (lyophile) containing trehalose and sodium citrate buffer [8].
  • We also developed conditions for detecting reversions by pH shift using bromocresol purple and by directly detecting the enzymatic activity of beta-lactamase using nitrocefin [9].

Biological context of BROMOMETHYLPHENOL


Anatomical context of BROMOMETHYLPHENOL

  • The kinetics of the protonation changes and of the formation of the metarhodopsin II intermediate are measured in the presence of the pH indicator dye bromocresol purple after two consecutive flashes on the same suspension of right-side-out vesicles from cattle rod-outer-segment membranes [14].
  • Serum albumin (bromocresol green) and CRP, age, dialysate to plasma (D/P) creatinine ratio, normalized protein catabolic rate (nPCR), daily urine and peritoneal protein losses, and extracellular fluid volume (Vecf) were measured in each patient [15].
  • Dimer formation of bromocresol purple anions on the phosphorylated intermediate of sarcoplasmic reticulum [16].
  • Serum free tri-iodothyronine (FT3), using two different radioimmunoassays, and serum albumin, using bromocresol green dye-binding method, were measured prospectively in 1374 adults investigated for thyroid disease [17].
  • It is proposed that bromocresol green, and probably also amaranth, rapidly equilibrates between the hepatic and biliary compartments as a result of reabsorption from the biliary tree and that the rate-limiting factor in the biliary excretion of these dyes is the removal of dye from the biliary tree by bulk flow [18].

Associations of BROMOMETHYLPHENOL with other chemical compounds

  • This latter aspect of the instrument is demonstrated by successfully determining the excited-state intensity decay kinetics for a dilute aqueous solution of rhodamine 6G dissolved in a high concentration of bromocresol green [19].
  • The use of a mixed pH indicator containing bromocresol purple and bromothymol blue was evaluated for the detection of beta-lactamase activity in enzyme immunoassays (EIA) based on this enzyme [20].
  • The bound enzyme activity can then be measured using a substrate solution containing urea and a pH indicator, most suitably bromocresol purple [21].
  • Miso, a widely used Japanese fermented food was analysed for its lactic acid bacterial count on bromocresol purple agar [22].
  • Two reagents, starch-iodine complex (SIC) and a mixed pH indicator, containing bromocresol purple and BTB (2:1) used earlier for the PNC-based ELISA, were compared with BTB for utilization in the PNC-based ELISA [23].


  • Unlike the yeast orthologue, SAMC catalysed virtually only countertransport, exhibited a higher transport affinity for SAM and was strongly inhibited by tannic acid and Bromocresol Purple [24].
  • METHODS: FSH, LH, SHBG by IRMA kits (DPC); E2, T, DHEAS, D4-A by RIA kits (Sorin Biomedica) after celite microcolumn chromatography; fT by coat-A-count kit (DPC); fE2 by equilibrium dialysis; serum albumin by bromocresol-green colorimetric methods [25].
  • Bromocresol green, an inhibitor of prostaglandin transporter (PGT), strongly decreased [(3)H]PGE(1) transport across the BBB [26].
  • The introduction of bromocresol purple for the determination of serum albumin on SMAC and ACA, and the standardization procedure [27].
  • Moreover in quality control and calibration procedures, strong deviations from the recommended values are obtained when non-human sera are analyzed with the bromocresol purple method [28].

Analytical, diagnostic and therapeutic context of BROMOMETHYLPHENOL


  1. Characteristics and biotypes of Pasteurella multocida isolated from humans. Oberhofer, T.R. J. Clin. Microbiol. (1981) [Pubmed]
  2. Problems associated with plasma albumin estimation in nephrotic syndrome using the bromocresol green method. Agbedana, E.O., Oshota, J.O., Taylor, G.O. African journal of medicine and medical sciences. (1993) [Pubmed]
  3. Underestimation of albumin content by bromocresol green, induced by drug displacers and uremia. Calvo, R., Carlos, R., Erill, S. International journal of clinical pharmacology, therapy, and toxicology. (1985) [Pubmed]
  4. PAH secretion in the urinary bladder of a crab Cancer borealis. Miller, D.S., Holliday, C.W. Am. J. Physiol. (1982) [Pubmed]
  5. Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state. Arnis, S., Hofmann, K.P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Proton transfer reactions linked to rhodopsin activation. Szundi, I., Mah, T.L., Lewis, J.W., Jäger, S., Ernst, O.P., Hofmann, K.P., Kliger, D.S. Biochemistry (1998) [Pubmed]
  7. Microsporum equinum in North America. Kane, J., Padhye, A.A., Ajello, L. J. Clin. Microbiol. (1982) [Pubmed]
  8. Impact of freeze-drying on ionization of sulfonephthalein probe molecules in trehalose-citrate systems. Govindarajan, R., Chatterjee, K., Gatlin, L., Suryanarayanan, R., Shalaev, E.Y. Journal of pharmaceutical sciences. (2006) [Pubmed]
  9. Further development of the beta-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and the umu test. Reifferscheid, G., Arndt, C., Schmid, C. Environ. Mol. Mutagen. (2005) [Pubmed]
  10. Specific association of bromocresol purple anions with a magnesium complex of a phosphorylated intermediate during steady-state hydrolysis of ATP by the Mg2+ + Ca2+-dependent ATPase of sarcoplasmic reticulum. Nakamaru, Y., Sato, C. J. Biochem. (1982) [Pubmed]
  11. Nutrition counseling impacts serum albumin levels. Akpele, L., Bailey, J.L. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. (2004) [Pubmed]
  12. A new photometric assay with bromocresol purple for testing in vitro antitrichomonal activity in aerobic environment. Loiseau, P.M., Bories, C., Sanon, A. Arzneimittel-Forschung. (1999) [Pubmed]
  13. The genetic characteristics Saccharomyces cerevisiae aci(+) mutants. Grochowalska, R., Machnicka, B., Wysocki, R., Lachowicz, T.M. Cell. Mol. Biol. Lett. (2003) [Pubmed]
  14. Optical study of the light-induced protonation changes associated with the metarhodopson II intermediate in rod-outer-segment membranes. Bennett, N. Eur. J. Biochem. (1980) [Pubmed]
  15. Extracellular fluid volume determined by bioelectric impedance and serum albumin in CAPD patients. Jones, C.H., Smye, S.W., Newstead, C.G., Will, E.J., Davison, A.M. Nephrol. Dial. Transplant. (1998) [Pubmed]
  16. Dimer formation of bromocresol purple anions on the phosphorylated intermediate of sarcoplasmic reticulum. Nakamaru, Y. J. Biochem. (1977) [Pubmed]
  17. Serum albumin and the specificity of free tri-iodothyronine as a test for hypothyroidism. Wright, D.J., Biddulph, L., Rinsler, M.G. Ann. Clin. Biochem. (1989) [Pubmed]
  18. Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat. Clark, A.G., Rogers, K.M. Aust. J. Biol. Sci. (1975) [Pubmed]
  19. A parallel multiharmonic frequency-domain fluorometer for measuring excited-state decay kinetics following one-, two-, or three-photon excitation. Watkins, A.N., Ingersoll, C.M., Baker, G.A., Bright, F.V. Anal. Chem. (1998) [Pubmed]
  20. An evaluation of the use of a pH indicator for the detection of beta-lactamase in enzyme immunoassay. Premier, R.R., Cox, J.C., Aitken, D.P., Healey, K. J. Immunol. Methods (1985) [Pubmed]
  21. A rapid semi quantitative capillary enzyme immunoassay for digoxin. Healey, K., Chandler, H.M., Cox, J.C., Hurrell, J.G. Clin. Chim. Acta (1983) [Pubmed]
  22. Binding of heterocyclic amines by lactic acid bacteria from miso, a fermented Japanese food. Rajendran, R., Ohta, Y. Can. J. Microbiol. (1998) [Pubmed]
  23. Penicillinase-based enzyme-linked immunosorbent assay for the detection of plant viruses. Sudarshana, M.R., Reddy, D.V. J. Virol. Methods (1989) [Pubmed]
  24. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. Agrimi, G., Di Noia, M.A., Marobbio, C.M., Fiermonte, G., Lasorsa, F.M., Palmieri, F. Biochem. J. (2004) [Pubmed]
  25. Endocrine changes in postmenopausal women after high-dose danazol therapy. Rigano, A., Sturlese, E., Rigano, M., Baviera, G. Panminerva medica. (1999) [Pubmed]
  26. Transport of prostaglandin E1 across the blood-brain barrier in rats. Taogoshi, T., Nomura, A., Murakami, T., Nagai, J., Takano, M. J. Pharm. Pharmacol. (2005) [Pubmed]
  27. The introduction of bromocresol purple for the determination of serum albumin on SMAC and ACA, and the standardization procedure. Assink, H.A., Blijenberg, B.G., Boerma, G.J., Leijnse, B. J. Clin. Chem. Clin. Biochem. (1984) [Pubmed]
  28. Bromocresol purple, a non-specific colour reagent for the determination of serum albumin. Tel, R.M., de Jong, J., Berends, G.T. J. Clin. Chem. Clin. Biochem. (1979) [Pubmed]
  29. Measurement of serum albumin by capillary zone electrophoresis, bromocresol green, bromocresol purple, and immunoassay methods. Duly, E.B., Grimason, S., Grimason, P., Barnes, G., Trinick, T.R. J. Clin. Pathol. (2003) [Pubmed]
  30. Clinical Oral Doses of Dexamethasone Decreases Intrinsic Clearance of Quinidine, A Cytochrome P450 3A Substrate in Dogs. Zhang, K., Kohno, S., Kuroha, M., Kokue, E., Shimoda, M. J. Vet. Med. Sci. (2006) [Pubmed]
  31. Serum albumin values from healthy cattle, sheep and horses determined by the immediate bromocresol green reaction and by agarose gel electrophoresis. Keay, G., Doxey, D.L. Res. Vet. Sci. (1983) [Pubmed]
  32. IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects. Kim, H.Y., Nahm, D.H., Suh, K.S., Park, H.S. Korean J. Intern. Med. (1998) [Pubmed]
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