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Chemical Compound Review

CHEMBL389895     [(2S,3R,4S,5R,6R)-3,5- dihydroxy-2-(3,4,5...

Synonyms: MEGxp0_001387, AC1L9QHF, AC-20241, NP-005114, ACon1_002062, ...
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Disease relevance of Tannin

  • Hamster embryo fibroblasts, transformed by wild-type or temperature-sensitive mutant (A28) SV40 virus, and human lung fibroblasts (WI-38, MRC-5) were studied using the tannic acid method of Simionescu and Simionescu (1976), which preferentially stained external carbohydrates [1].
  • The chloroform-methanol fraction prepared from urine of rats fed BF, chloroform fraction of BF, or tannin-free fraction of BF demonstrated mutagenicity for Salmonella typhimurium TA 100 but not for TA 98 [2].
  • Type B and type C RNA tumor virus replication in single cells. Electron microscopy with tannic acid [3].
  • F344 rats in group 8 received weekly sc injections of tannin solution (0.1 g/kg body wt) for 38 weeks, and 16/20 developed palpable tumors that were malignant fibrous histiocytomas at the injection site [2].
  • Periodic densities spaced at comparable distances are seen in PtK2 and in gerbil fibroma cells when they are treated with tannic acid and examined in the electron microscope [4].

Psychiatry related information on Tannin

  • Our findings suggest that the usual intake of polyphenols is relatively safe, but that a high intake by supplementation or by dietary habit of tannin affects only the Fe level [5].
  • Since geraniin and corilagin have been well investigated as representative tannins, we discuss here the new possibility of classical herbal medicine in the development of preventive agents for cancer and other life-style related diseases [6].

High impact information on Tannin


Chemical compound and disease context of Tannin


Biological context of Tannin


Anatomical context of Tannin


Associations of Tannin with other chemical compounds


Gene context of Tannin


Analytical, diagnostic and therapeutic context of Tannin


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  3. Type B and type C RNA tumor virus replication in single cells. Electron microscopy with tannic acid. Schidlovsky, G., Shibley, G.P., Benton, C.V., Elser, J.E. J. Natl. Cancer Inst. (1978) [Pubmed]
  4. Differences in the stress fibers between fibroblasts and epithelial cells. Sanger, J.W., Sanger, J.M., Jockusch, B.M. J. Cell Biol. (1983) [Pubmed]
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  7. A. thaliana TRANSPARENT TESTA 1 is involved in seed coat development and defines the WIP subfamily of plant zinc finger proteins. Sagasser, M., Lu, G.H., Hahlbrock, K., Weisshaar, B. Genes Dev. (2002) [Pubmed]
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  12. Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin. Shimizu, M., Shiota, S., Mizushima, T., Ito, H., Hatano, T., Yoshida, T., Tsuchiya, T. Antimicrob. Agents Chemother. (2001) [Pubmed]
  13. Specific PCR assay for a tannin-tolerant selenomonas ruminantium isolate, derived from helicase coding sequences. Bishop, R., Obura, M., Odongo, D., Odenyo, A. Appl. Environ. Microbiol. (2004) [Pubmed]
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  15. Increasing the oxidative stress response allows Escherichia coli to overcome inhibitory effects of condensed tannins. Smith, A.H., Imlay, J.A., Mackie, R.I. Appl. Environ. Microbiol. (2003) [Pubmed]
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  21. Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway. Taffetani, S., Ueno, Y., Meng, F., Venter, J., Francis, H., Glaser, S., Alpini, G., Patel, T. Am. J. Pathol. (2005) [Pubmed]
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  33. Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity. Chen, X., Beutler, J.A., McCloud, T.G., Loehfelm, A., Yang, L., Dong, H.F., Chertov, O.Y., Salcedo, R., Oppenheim, J.J., Howard, O.M. Clin. Cancer Res. (2003) [Pubmed]
  34. Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. Rapizzi, E., Fossati, S., Moroni, F., Chiarugi, A. Mol. Pharmacol. (2004) [Pubmed]
  35. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Afaq, F., Saleem, M., Krueger, C.G., Reed, J.D., Mukhtar, H. Int. J. Cancer (2005) [Pubmed]
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