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Gene Review:

WDFY2 - WD repeat and FYVE domain containing 2

Homo sapiens

Synonyms: PROF, WD repeat and FYVE domain-containing protein 2, WD40-and FYVE domain-containing protein 2, WDF2, ZFYVE22, ...

Hayakawa, A. et al.

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High impact information on WDFY2

These studies reveal the important, conserved role of WDFY2 in endocytosis, and the existence of a subset of early endosomes, closely associated with the plasma membrane, that may constitute the first stage of endocytic processing of internalized cargo [1].
Silencing of WDFY2 by siRNA in mammalian cells impaired transferrin endocytosis [1].

Biological context of WDFY2

One protein, WDFY2, produced a strong inhibition of endocytosis when silenced [1].

Anatomical context of WDFY2

WDFY2 contains WD40 motifs and a FYVE domain, is highly conserved between species, and localizes to a set of small endosomes that reside within 100 nm from the plasma membrane [1].

References

The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa, A., Leonard, D., Murphy, S., Hayes, S., Soto, M., Fogarty, K., Standley, C., Bellve, K., Lambright, D., Mello, C., Corvera, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP008932	Anopheles gambiae str. PEST
wdfy-2	Caenorhabditis elegans
WDFY2	Canis lupus familiaris
wdfy2	Danio rerio
CG5168	Drosophila melanogaster
WDFY2	Gallus gallus
LOC708929	Macaca mulatta
Wdfy2	Mus musculus
WDFY2	Pan troglodytes
Wdfy2	Rattus norvegicus
wdfy2	Xenopus (Silurana) tropicalis

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