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Gene Review

WDFY2  -  WD repeat and FYVE domain containing 2

Homo sapiens

Synonyms: PROF, WD repeat and FYVE domain-containing protein 2, WD40-and FYVE domain-containing protein 2, WDF2, ZFYVE22, ...
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High impact information on WDFY2


Biological context of WDFY2


Anatomical context of WDFY2

  • WDFY2 contains WD40 motifs and a FYVE domain, is highly conserved between species, and localizes to a set of small endosomes that reside within 100 nm from the plasma membrane [1].


  1. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa, A., Leonard, D., Murphy, S., Hayes, S., Soto, M., Fogarty, K., Standley, C., Bellve, K., Lambright, D., Mello, C., Corvera, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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