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Gene Review:

pagA - protective antigen

Bacillus anthracis str. A2012

Chen, K.H. et al., Laughlin, E.M. et al., Go, M.Y. et al., Rivera, J. et al., Kobiler, D. et al.

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Disease relevance of pagA

Selection of Anthrax Toxin Protective Antigen Variants That Discriminate between the Cellular Receptors TEM8 and CMG2 and Achieve Targeting of Tumor Cells [1].
Protective antigen (PA), lethal factor (LF) and edema factor (EF) are secreted individually by Bacillus anthracis [2].
Protective antigen (PA) is essential for the action of B. anthracis lethal toxin (LeTx) and edema toxin [3].

Anatomical context of pagA

Antigen-Specific CD4+ T Cells Recognize Epitopes of Protective Antigen following Vaccination with an Anthrax Vaccine [4].

Analytical, diagnostic and therapeutic context of pagA

Protective antigen as a correlative marker for anthrax in animal models [5].

References

Selection of Anthrax Toxin Protective Antigen Variants That Discriminate between the Cellular Receptors TEM8 and CMG2 and Achieve Targeting of Tumor Cells. Chen, K.H., Liu, S., Bankston, L.A., Liddington, R.C., Leppla, S.H. J. Biol. Chem. (2007) [Pubmed]
Self-association of the transmembrane domain of an anthrax toxin receptor. Go, M.Y., Kim, S., Partridge, A.W., Melnyk, R.A., Rath, A., Deber, C.M., Mogridge, J. J. Mol. Biol. (2006) [Pubmed]
A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Rivera, J., Nakouzi, A., Abboud, N., Revskaya, E., Goldman, D., Collier, R.J., Dadachova, E., Casadevall, A. Infect. Immun. (2006) [Pubmed]
Antigen-Specific CD4+ T Cells Recognize Epitopes of Protective Antigen following Vaccination with an Anthrax Vaccine. Laughlin, E.M., Miller, J.D., James, E., Fillos, D., Ibegbu, C.C., Mittler, R.S., Akondy, R., Kwok, W., Ahmed, R., Nepom, G. Infect. Immun. (2007) [Pubmed]
Protective antigen as a correlative marker for anthrax in animal models. Kobiler, D., Weiss, S., Levy, H., Fisher, M., Mechaly, A., Pass, A., Altboum, Z. Infect. Immun. (2006) [Pubmed]

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