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Gene Review:

Cntn4 - contactin 4

Rattus norvegicus

Synonyms: Axcam, BIG-2, Big-2, Brain-derived immunoglobulin superfamily protein 2, Contactin-4

Yoshihara, Y. et al., Ogawa, J. et al.

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High impact information on Cntn4

Recombinant BIG-2 protein had a neurite outgrowth-promoting activity when used as a substrate for neurons in vitro [1].
NB-2 shared 46, 43, 55 and 55% identities with Contactin/F3, Tag-1, Big-1 and Big-2, respectively, at the amino acid sequence level [2].

Analytical, diagnostic and therapeutic context of Cntn4

We report here a molecular cloning of a novel AxCAM, BIG-2 [1].

References

Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. Yoshihara, Y., Kawasaki, M., Tamada, A., Nagata, S., Kagamiyama, H., Mori, K. J. Neurobiol. (1995) [Pubmed]
Novel neural adhesion molecules in the Contactin/F3 subgroup of the immunoglobulin superfamily: isolation and characterization of cDNAs from rat brain. Ogawa, J., Kaneko, H., Masuda, T., Nagata, S., Hosoya, H., Watanabe, K. Neurosci. Lett. (1996) [Pubmed]

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