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Gene Review

Cntn4  -  contactin 4

Mus musculus

Synonyms: 9630050B05, Axcam, BIG-2, BIG-2A, Brain-derived immunoglobulin superfamily protein 2, ...
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Disease relevance of Cntn4

  • Our findings suggest a role for human contactin 4 protein in the response of neuroblastoma cells to differentiating agents [1].

High impact information on Cntn4

  • A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia [2].
  • We have cloned a mouse cDNA encoding a novel truncated form of the gene BIG-2 from the vomeronasal organ [2].
  • These results suggest that alternative splicing of the BIG-2 gene transcript may play an important role in the organization of the vomeronasal and olfactory neuroepithelia [2].

Analytical, diagnostic and therapeutic context of Cntn4

  • To determine the expression of this gene, in situ hybridization analysis was performed in adult and developing mice using a riboprobe specific for BIG-2A [2].


  1. Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2). Hansford, L.M., Smith, S.A., Haber, M., Norris, M.D., Cheung, B., Marshall, G.M. Cytogenet. Genome Res. (2003) [Pubmed]
  2. A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Mimmack, M.L., Saito, H., Evans, G., Bresler, M., Keverne, E.B., Emson, P.C. Brain Res. Mol. Brain Res. (1997) [Pubmed]
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