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Gene Review

Trim28  -  tripartite motif-containing 28

Rattus norvegicus

Synonyms: E3 SUMO-protein ligase TRIM28, KRAB-associated protein 1, Kap1, Krip1, Nuclear corepressor KAP-1, ...
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High impact information on Trim28

  • MM-1 has been reported to repress the E-box-dependent transcription activity of c-Myc by recruiting histone deacetylase 1 complex via TIF1beta/KAP1 [1].
  • On the basis of results from a previous study, we conclude that this novel KRAB domain strengthens the interaction with TIF1beta, thereby improving the ability of these KRAB zinc finger proteins to recruit TIF1beta to specific sites [2].


  1. Repression of the c-fms gene in fibroblast cells by c-Myc-MM-1-TIF1beta complex. Satou, A., Hagio, Y., Taira, T., Iguchi-Ariga, S.M., Ariga, H. FEBS Lett. (2004) [Pubmed]
  2. A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins. Looman, C., Hellman, L., Abrink, M. Mamm. Genome (2004) [Pubmed]
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